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Comparison of the pericapsular nerve group block with the intra-articular and quadratus lumborum blocks in primary total hip arthroplasty: a randomized controlled trial
Tayfun Et, Muhammet Korkusuz
Korean J Anesthesiol. 2023;76(6):575-585.

Review Article

April 19, 2023


Pediatric perioperative fluid management
Hyungmook Lee, Jin Tae Kim
Korean J Anesthesiol. 2023;76(6):519-530.

The purpose of perioperative fluid management in children is to maintain adequate volume status, electrolyte level, and endocrine system homeostasis during the perioperative period. Although hypotonic solutions containing glucose have traditionally been used as pediatric maintenance fluids, recent studies have shown that isotonic balanced crystalloid solutions lower the risk of hyponatremia and metabolic acidosis perioperatively. Isotonic balanced solutions have been found to exhibit safer and more physiologically appropriate characteristics for perioperative fluid maintenance and replacement. Additionally, adding 1–2.5% glucose to the maintenance fluid can help prevent children from developing hypoglycemia as well as lipid mobilization, ketosis, and hyperglycemia. The fasting time should be as short as possible without compromising safety;...

Statistical Round

November 14, 2023


Intention-to-treat versus as-treated versus per-protocol approaches to analysis
EunJin Ahn, Hyun Kang
Korean J Anesthesiol. 2023;76(6):531-539.

Randomized controlled trials (RCTs) are considered the most rigorous study design for testing hypotheses and the gold standard for evaluating intervention effectiveness. However, RCTs are often conducted under the assumption of ideal conditions that may differ from real-world scenarios in which various issues, such as loss to follow-up, mistakes in participant enrollment or intervention, and low subject compliance or adherence, may occur. There are various group-defining strategies for analyzing RCT data, including the intention-to-treat (ITT), as-treated, and per-protocol (PP) approaches. The ITT principle involves analyzing all participants according to their initial group assignments, regardless of study completion and compliance or adherence to treatment protocols. This approach aims to replicate real-world...

Clinical Research Article

September 26, 2023


Predicting optimal endotracheal tube size and depth in pediatric patients using demographic data and machine learning techniques
Hyeonsik Kim, Hyun-Kyu Yoon, Hyeonhoon Lee, Chul-Woo Jung, Hyung-Chul Lee
Korean J Anesthesiol. 2023;76(6):540-549.

Background: Use of endotracheal tubes (ETTs) with appropriate size and depth can help minimize intubation-related complications in pediatric patients. Existing age-based formulae for selecting the optimal ETT size present several inaccuracies. We developed a machine learning model that predicts the optimal size and depth of ETTs in pediatric patients using demographic data, enabling clinical applications. Methods: Data from 37,057 patients younger than 12 years who underwent general anesthesia with endotracheal intubation were retrospectively analyzed. Gradient boosted regression tree (GBRT) model was developed and compared with traditional age-based formulae. Results: The...

Clinical Research Article

February 24, 2023


Association between inflammation-based prognostic markers and mortality of non-cardiac surgery
Ah Ran Oh, Jungchan Park, Jong-Hwan Lee, Kwangmo Yang, Joonghyun Ahn, et al.
Korean J Anesthesiol. 2023;76(6):550-558.

Background: To evaluate the association between inflammation and nutrition-based biomarkers and postoperative outcomes after non-cardiac surgery. Methods: Between January 2011 and June 2019, a total of 102,052 patients undergoing non-cardiac surgery were evaluated, with C-reactive protein (CRP), albumin, and complete blood count (CBC) measured within six months before surgery. We assessed their CRP-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and modified Glasgow Prognostic Score (mGPS). We determined the best cut-off values by using the receiver operating characteristic (ROC) curves. Patients were divided into high and low groups according to the estimated threshold, and we compared the one-year mortality. Results: The one-year mortality of the entire sample was 4.2%. ROC analysis...

Clinical Research Article

April 24, 2023


Does intravenous patient-controlled analgesia or continuous block prevent rebound pain following infraclavicular brachial plexus block after distal radius fracture fixation? A prospective randomized controlled trial
Jong-hyuk Lee, Ha-jung Kim, Jae Kwang Kim, Sungjoo Cheon, Young Ho Shin
Korean J Anesthesiol. 2023;76(6):559-566.

Background: The purpose of this study was to investigate the role of opioid-based intravenous patient-controlled analgesia (IV PCA) or continuous brachial plexus block (BPB) in controlling rebound pain after distal radius fracture (DRF) fixation under BPB as well as total opioid consumption. Methods: A total of 66 patients undergoing surgical treatment for a displaced DRF with volar plate fixation were randomized to receive a single infraclavicular BPB (BPB only group) (n = 22), a single infraclavicular BPB with IV PCA (IV PCA group) (n = 22), or a single infraclavicular...

Clinical Research Article

May 10, 2023


Quality of recovery in hospital and disability-free survival at three months after major abdominal surgery
Yuki Kinugasa, Mitsuru Ida, Shohei Nakatani, Kayo Uyama, Masahiko Kawaguchi
Korean J Anesthesiol. 2023;76(6):567-574.

Background: The Quality of Recovery-15 (QoR-15) and 12-item World Health Organization Disability Assessment Schedule 2.0 scales are post-surgery patient-reported outcome measures. We aimed to evaluate the association between immediate in-hospital postoperative recovery and mid-term disability-free survival (DFS) after discharge. Methods: We conducted a prospective observational study at a university hospital and enrolled 260 patients aged ≥ 65 years with cancer who were undergoing elective major abdominal surgery. The association between poor postoperative recovery, defined as a QoR-15 score < 90 on postoperative day (POD) 2, and the DFS three months later was assessed using Fisher’s exact test. The odds ratio of poor recovery on POD 2 to DFS was calculated using...

Clinical Research Article

April 4, 2023


Comparison of the pericapsular nerve group block with the intra-articular and quadratus lumborum blocks in primary total hip arthroplasty: a randomized controlled trial
Tayfun Et, Muhammet Korkusuz
Korean J Anesthesiol. 2023;76(6):575-585.

Background: The pericapsular nerve group (PENG) block, quadratus lumborum block (QLB), and intra-articular (IA) local anesthetic injection have been shown to provide effective analgesia in total hip arthroplasty (THA). This randomized study aimed to compare the analgesic efficacy, motor protection, and quality of recovery associated with the PENG block, QLB, and IA injection. Methods: Eighty-nine patients who underwent a unilateral primary THA under spinal anesthesia were randomly assigned to the PENG (n=30), QLB (n=30), or IA (n=29) group. The primary outcome was the numerical rating scale (NRS) score over the first...

Clinical Research Article

March 16, 2023


Effects of dexmedetomidine on pulmonary function in patients receiving one-lung ventilation: a meta-analysis of randomized controlled trial
Lin Yang, Yongheng Cai, Lin Dan, He Huang, Bing Chen
Korean J Anesthesiol. 2023;76(6):586-596.

Background: Mechanical ventilation, particularly one-lung ventilation (OLV), can cause pulmonary dysfunction. This meta-analysis assessed the effects of dexmedetomidine on the pulmonary function of patients receiving OLV. Methods: The Embase, PubMed, MEDLINE, Cochrane Library, ClinicalTrials.gov, and Chinese Clinical Trial Registry databases were systematically searched. The primary outcome was oxygenation index (OI). Other outcomes including the incidence of postoperative complications were assessed. Results: Fourteen randomized controlled trials involving 845 patients were included in this meta-analysis. Dexmedetomidine improved the OI at 30 (mean difference [MD]: 40.49, 95% CI [10.21, 70.78]), 60 (MD: 60.86,...

Clinical Research Article

April 17, 2023


Comparison of different nonsteroidal anti-inflammatory drugs for cesarean section: a systematic review and network meta-analysis
Iona Murdoch, Anthony L Carver, Pervez Sultan, James E O’Carroll, Lindsay Blake, et al.
Korean J Anesthesiol. 2023;76(6):597-616.

Background: Cesarean section is associated with moderate to severe pain and nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly employed. The optimal NSAID, however, has not been elucidated. In this network meta-analysis and systematic review, we compared the influence of control and individual NSAIDs on the indices of analgesia, side effects, and quality of recovery. Methods: CDSR, CINAHL, CRCT, Embase, LILACS, PubMed, and Web of Science were searched for randomized controlled trials comparing a specific NSAID to either control or another NSAID in elective or emergency cesarean section under general or neuraxial anesthesia. Network plots and league tables were constructed, and the quality of evidence was evaluated with Grading of Recommendations Assessment, Development...

Clinical Research Article

December 21, 2022


Effect of magnesium sulfate on oxygenation and lung mechanics in morbidly obese patients undergoing bariatric surgery: a prospective double-blind randomized clinical trial
Marwa M. Mowafi, Marwa A. K. Elbeialy, Rasha Gamal Abusinna
Korean J Anesthesiol. 2023;76(6):617-626.

Background: Respiratory mechanics are often significantly altered in morbidly obese patients and magnesium sulfate (MgSO4) is a promising agent for managing several respiratory disorders. This study aimed to examine the effects of MgSO4 infusions on arterial oxygenation and lung mechanics in patients with morbid obesity undergoing laparoscopic bariatric surgery. Methods: Forty patients with morbid obesity aged 21–60 years scheduled for laparoscopic bariatric surgery under general anesthesia were randomly allocated to either the control (normal saline infusion) or MgSO4 group (30 mg/kg lean body weight [LBW] of...

Experimental Research Article

August 21, 2023


Effects of sevoflurane on metalloproteinase and natural killer group 2, member D (NKG2D) ligand expression and natural killer cell-mediated cytotoxicity in breast cancer: an in vitro study
Hyae Jin Kim, Soeun Jeon, Hyeon Jeong Lee, Jaeho Bae, Hyun-Su Ri, et al.
Korean J Anesthesiol. 2023;76(6):627-639.

Background: We investigated the effects of sevoflurane exposure on the expression of matrix metalloproteinase (MMP), expression and ablation of natural killer group 2, member D (NKG2D) ligands (UL16-binding proteins 1–3 and major histocompatibility complex class I chain-related molecules A/B), and natural killer (NK) cell-mediated cytotoxicity in breast cancer cells. Methods: Three human breast cancer cell lines (MCF-7, MDA-MB-453, and HCC-70) were incubated with 0 (control), 600 (S6), or 1200 μM (S12) sevoflurane for 4 h. The gene expression of NKG2D ligands and their protein expression on cancer cell surfaces were measured...
Comparison of the pericapsular nerve group block with the intra-articular and quadratus lumborum blocks in primary total hip arthroplasty: a randomized controlled trial
Tayfun Et, Muhammet Korkusuz
Korean J Anesthesiol. 2023;76(6):575-585.

Clinical Research Article

April 4, 2023
Usefulness of C-curved stylet for intubation with the C-MAC® Miller videolaryngoscope in neonates and infants: a prospective randomized controlled trial
Jung-Bin Park, Pyo-Yoon Kang, Taeyup Kim, Sang-Hwan Ji, Young-Eun Jang, Eun-Hee Kim, Jin-Tae Kim, Hee-Soo Kim, Ji Hyun Lee
Korean J Anesthesiol. 2023;76(5):433-441.

Clinical Research Article

December 23, 2022
Effect of patient decision aids on choice between sugammadex and neostigmine in surgeries under general anesthesia: a multicenter randomized controlled trial
Li-Kai Wang, Yao-Tsung Lin, Jui-Tai Chen, Winnie Lan, Kuo-Chuan Hung, Jen-Yin Chen, Kuei-Jung Liu, Yu-Chun Yen, Yun-Yun Chou, Yih-Giun Cherng, et al.
Korean J Anesthesiol. 2023;76(4):280-289.

Clinical Research Article

December 5, 2022
Preemptive visceral analgesic effect of thoracic paravertebral block on postoperative opioid consumption in patients undergoing laparoscopic cholecystectomy: a prospective, randomized, assessor-blind study
Jong-Hyuk Lee, Chan-Sik Kim, Hyungtae Kim, Jae Moon Choi, Youngmu Kim, Sung-Moon Jeong, Seong-Soo Choi
Korean J Anesthesiol. 2023;76(3):203-212.

Clinical Research Article

December 21, 2022
Retrospective analysis of the incidence and predictors of postoperative nausea and vomiting after orthopedic surgery under spinal anesthesia
Jae-Woo Ju, Jina Kwon, Seokha Yoo, Ho-Jin Lee
Korean J Anesthesiol. 2023;76(2):99-106.

Clinical Research Article

July 13, 2022
Single-shot regional anesthesia for laparoscopic cholecystectomies: a systematic review and network meta-analysis
Alessandro De Cassai, Nicolò Sella, Federico Geraldini, Serkan Tulgar, Ali Ahiskalioglu, Burhan Dost, Silvia Manfrin, Yunus Emre Karapinar, Greta Paganini, Muzeyyen Beldagli, et al.
Korean J Anesthesiol. 2023;76(1):34-46.

Clinical Research Article

November 8, 2022
Determination of the 95% effective dose of remimazolam to achieve loss of consciousness during anesthesia induction in different age groups
Juyeon Oh, Sung Yong Park, Sook Young Lee, Ju Yeol Song, Ga Yun Lee, Ji Hyun Park, Han Bum Joe
Korean J Anesthesiol. 2022;75(6):510-517.

Clinical Research Article

August 1, 2022
Prognostic value of left ventricular apical four-chamber longitudinal strain after heart valve surgery in real-world practice
Jae-Sik Nam, Ji-Hyun Chin, Hyun-Uk Kang, Juyoun Kim, Kyoung-Woon Joung, In-Cheol Choi
Korean J Anesthesiol. 2022;75(5):416-426.

Clinical Research Article

June 15, 2022
Video laryngoscope versus USB borescope-aided endotracheal intubation in adults with anticipated difficult airway: a prospective randomized controlled study
Mohamed Elshazly, Mark Medhat, Sahar Marzouk, Enas M. Samir
Korean J Anesthesiol. 2022;75(4):331-337.

Clinical Research Article

May 18, 2022
The effect of ultrasound-guided bilateral thoracic retrolaminar block on analgesia after pediatric open cardiac surgery: a randomized controlled double-blind study
Ibrahim Abdelbaser, Nabil A. Mageed, Sherif I. Elfayoumy, Mohamed Magdy, Mohamed M. Elmorsy, Mahmoud M. ALseoudy
Korean J Anesthesiol. 2022;75(3):276-282.

Clinical Research Article

January 12, 2022
Effect of chemotherapy on effect-site concentration of propofol for loss of consciousness in patients with colorectal cancer
Seunghee Ki, Yongwon Cho, Youngkyung Choi, Sehun Lim, Myounghun Kim, Jeonghan Lee
Korean J Anesthesiol. 2022;75(2):160-167.

Clinical Research Article

September 17, 2021
Effect of postoperative non-steroidal anti-inflammatory drugs on anastomotic leakage after pancreaticoduodenectomy
Susie Yoon, Hyerin Kim, Hye-Yeon Cho, Ho-Jin Lee, Hongbeom Kim, Hyung-Chul Lee, Jin-Young Jang
Korean J Anesthesiol. 2022;75(1):61-70.

Clinical Research Article

May 24, 2021
Analysis of endotracheal intubation-related judicial precedents in South Korea
Hye-Yeon Cho, SuHwan Shin, SangJin Lee, Susie Yoon, Ho-Jin Lee
Korean J Anesthesiol. 2021;74(6):506-513.

Clinical Research Article

March 25, 2021
Explanation of trial sequential analysis: using a post-hoc analysis of meta-analyses published in Korean Journal of Anesthesiology
Alessandro De Cassai, Martina Tassone, Federico Geraldini, Massimo Sergi, Nicolò Sella, Annalisa Boscolo, Marina Munari
Korean J Anesthesiol. 2021;74(5):383-393.

Clinical Research Article

July 20, 2021
Prediction of endotracheal tube size using a printed three-dimensional airway model in pediatric patients with congenital heart disease: a prospective, single-center, single-group study
Seyeon Park, Jisoo Ahn, Sung Uk Yoon, Ki Seok Choo, Hye-Jin Kim, Minwoo Chung, Hee Young Kim
Korean J Anesthesiol. 2021;74(4):333-341.

Clinical Research Article

May 31, 2021
Comparison between two different concentrations of a fixed dose of ropivacaine in interscalene brachial plexus block for pain management after arthroscopic shoulder surgery: a randomized clinical trial
Seung Cheol Lee, Joon Ho Jeong, Seong Yeop Jeong, Sung Wan Kim, Chan Jong Chung, So Ron Choi, Jeong Ho Kim, Sang Yoong Park
Korean J Anesthesiol. 2021;74(3):226-233.

Clinical Research Article

August 21, 2020
Four different methods of measuring cardiac index during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Amon Heijne, Piet Krijtenburg, Andre Bremers, Gert Jan Scheffer, Ignacio Malagon, Cornelis Slagt
Korean J Anesthesiol. 2021;74(2):120-133.

Clinical Research Article

August 21, 2020
Demographic and clinical factors associated with same-day discharge and unplanned readmission following shoulder arthroplasty: a retrospective cohort study
Brittany N. Burton, John J. Finneran, Aaron Angerstein, Evelyn Ross, Ana Mitchell, Ruth S. Waterman, Ahmad Elsharydah, Engy T. Said, Rodney A. Gabriel
Korean J Anesthesiol. 2021;74(1):30-37.

Clinical Research Article

March 12, 2020
Effects of hypercarbia on arterial oxygenation during one-lung ventilation: prospective randomized crossover study
Junho Lee, Yesull Kim, Juhan Mun, Joseph Lee, Seonghoon Ko
Korean J Anesthesiol. 2020;73(6):534-541.

Clinical Research Article

May 28, 2020
Randomized, controlled trial comparing respiratory and analgesic effects of interscalene, anterior suprascapular, and posterior suprascapular nerve blocks for arthroscopic shoulder surgery
Yean Chin Lim, Zhao Kun Koo, Vivian. W. Ho, See Seong Chang, Shivani Manohara, Qian Jun Tong
Korean J Anesthesiol. 2020;73(5):408-416.

Clinical Research Article

July 16, 2020
Influence of alcohol consumption on blood coagulation in rotational thromboelastometry (ROTEM): an in-vivo study
Hendrik Eismann, Lion Sieg, Hala Ahmed, Joerg Teske, Patrick Behrendt, Lars Friedrich, Carsten Schumacher, Kai Johanning
Korean J Anesthesiol. 2020;73(4):334-341.

Experimental Research Article

April 16, 2020
Whole-blood hypocoagulable profile correlates with a greater risk of death within 28 days in patients with severe sepsis
Annalisa Boscolo, Luca Spiezia, Elena Campello, Diana Bertini, Vittorio Lucchetta, Eleonora Piasentini, Alessandro De Cassai, Paolo Simioni
Korean J Anesthesiol. 2020;73(3):224-231.

Clinical Research Article

January 7, 2020
Neuromuscular blockade reversal with sugammadex versus pyridostigmine/ glycopyrrolate in laparoscopic cholecystectomy: a randomized trial of effects on postoperative gastrointestinal motility
Jihyun An, Heeyun Noh, Eunju Kim, Jihyang Lee, Kyeongyoon Woo, Hyunkyum Kim
Korean J Anesthesiol. 2020;73(2):137-144.

Clinical Research Article

October 22, 2019
Effect of anesthetic method on incidence of delirium after total hip replacement arthroplasty in South Korea: a population-based study using National Health Insurance claims data
Eun-Ji Choi, Yoon Ji Choi, Sang Won Lee, Yun-Mi Choi, Hyun-Su Ri, Ju Yeon Park, Soon Ji Park, Jung-Min Son, Yoon Sook Lee
Korean J Anesthesiol. 2020;73(1):36-43.

Clinical Research Article

August 3, 2019
Comparison of clinical performance of i-gelⓇ and Baska MaskⓇ during laparoscopic cholecystectomy
So Ron Choi, Tae Young Lee, Sung Wan Kim, Sang Yoong Park, Chan Jong Chung, Jeong Ho Kim
Korean J Anesthesiol. 2019;72(6):576-582.

Special Issue: Airway Management

Clinical Research Article

August 20, 2019
Programmed intermittent epidural bolus as compared to continuous epidural infusion for the maintenance of labor analgesia: a prospective randomized single-blinded controlled trial
Christina W. Fidkowski, Sonalee Shah, Mohamed-Rida Alsaden
Korean J Anesthesiol. 2019;72(5):472-478.

Clinical Research Article

June 20, 2019
The analgesic efficacy of the transversalis fascia plane block in iliac crest bone graft harvesting: a randomized controlled trial
Nicholas D. Black, Laith Malhas, Rongyu Jin, Anuj Bhatia, Vincent W. S. Chan, Ki Jinn Chin
Korean J Anesthesiol. 2019;72(4):336-343.

Clinical Research Article

March 19, 2019
Cerebrovascular reactivity to hypercapnia during sevoflurane or desflurane anesthesia in rats
Koji Sakata, Kazuhiro Kito, Naokazu Fukuoka, Kiyoshi Nagase, Kumiko Tanabe, Hiroki Iida
Korean J Anesthesiol. 2019;72(3):260-264.

Experimental Research Article

November 27, 2018
The effect of a mixture of 2.7% sorbitol-0.54% mannitol solution on blood coagulation: an invitro, observational healthyvolunteer study using rotational thromboelastometry (ROTEM)
Hyun-Jung Shin, Heijin Lee, Hyo-Seok Na
Korean J Anesthesiol. 2019;72(2):143-149.

Clinical Research Article

December 14, 2018
A prospective randomized controlled double-blind study comparing auscultation and lung ultrasonography in the assessment of double lumen tube position in elective thoracic surgeries involving one lung ventilation at a tertiary care cancer institute
Swapnil Y Parab, Prashant Kumar, Jigeeshu V. Divatia, Kailash Sharma
Korean J Anesthesiol. 2019;72(1):24-31.

Clinical Research Article

September 12, 2018
  • Journal Impact Factor 2.9
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  • Hemodynamic management during off-pump coronary artery bypass surgery: a narrative review of proper targets for safe execution and troubleshooting. Korean J Anesthesiol. 2023;76:267-279
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