Korean Journal of Anesthesiology

Effects of opioid-sparing general anesthesia on postoperative nausea and vomiting in laparoscopic gynecological surgery: Sun Woo Nam, Sang-Hwan Do, Jung-Won Hwang, Insun Park, Insung Hwang, et al.; Korean J Anesthesiol. 2024;77(6):605-613.

Review Article

April 26, 2024

Renal implications of pneumoperitoneum in laparoscopic surgery: mechanisms, risk factors, and preventive strategies

Gianluca Villa, Marco Fiorentino, Eleonora Cappellini, Sergio Lassola, Silvia De Rosa

Korean J Anesthesiol. 2024;77(6):575-586.

Pneumoperitoneum, which is established for laparoscopic surgery, has systemic implications on the renal system and may contribute to acute kidney injury or postoperative renal dysfunction. Specifically, when the pressure exceeds 10 mmHg, pneumoperitoneum decreases renal blood flow, leading to renal dysfunction and temporary oliguria. The renal effects of pneumoperitoneum stem from both the direct effects of increased intra-abdominal pressure and indirect factors such as carbon dioxide absorption, neuroendocrine influences, and tissue damage resulting from oxidative stress. While pneumoperitoneum can exacerbate renal dysfunction in patients with pre-existing kidney issues, preserving the function of the remaining kidney is crucial in certain procedures such as laparoscopic live donor nephrectomy. ...

Clinical Research Article

October 8, 2024

Comparison of remimazolam and midazolam for preventing intraoperative nausea and vomiting during cesarean section under spinal anesthesia: a randomized controlled trial

Kyuho Lee, Seung Ho Choi, Sangil Kim, Hae Dong Kim, Hyejin Oh, et al.

Korean J Anesthesiol. 2024;77(6):587-595.

Background: Preventing intraoperative nausea and vomiting (IONV) is crucial for maternal safety during cesarean section under spinal anesthesia. While midazolam is known to prevent IONV, we hypothesized that remimazolam would be superior due to its minimal hemodynamic effects. We compared the effects of the two drugs on IONV. Methods: Parturients scheduled for cesarean section were randomly assigned to receive either midazolam or remimazolam. They received midazolam 2 mg or remimazolam 5 mg, with additional doses administered upon request. The primary outcome measure was the incidence of newly developed IONV during sedation....

Clinical Research Article

August 21, 2024

Reverse tube direction and epistaxis in left nasotracheal intubation: a randomized controlled trial

Jun-Young Park, Jihion Yu, Chan-Sik Kim, Taeho Mun, Woo Shik Jeong, et al.

Korean J Anesthesiol. 2024;77(6):596-604.

Background: The incidence of epistaxis during nasotracheal intubation via the left nostril is more frequent than that during intubation via the right nostril. This study evaluated the effect of the reverse bevel and tip direction of the nasotracheal tube on the incidence of epistaxis during nasotracheal intubation via the left nostril. Methods: Patients undergoing right-sided maxillofacial surgery requiring left nasotracheal intubation were randomly allocated to the control (tracheal tube in the conventional direction) or reverse (a 180˚ reverse direction, with the tube bevel facing the nasal septum and the leading edge (i.e., the tip) of the bevel pointing away from the nasal septum) groups (n = 37 for both). The primary...

Clinical Research Article

August 23, 2024

Effects of opioid-sparing general anesthesia on postoperative nausea and vomiting in laparoscopic gynecological surgery

Sun Woo Nam, Sang-Hwan Do, Jung-Won Hwang, Insun Park, Insung Hwang, et al.

Korean J Anesthesiol. 2024;77(6):605-613.

Background: In this study, we aimed to investigate whether opioid-sparing anesthesia (OSA) reduces postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic gynecological surgery. Methods: Adult patients undergoing elective laparoscopic gynecological surgery were randomly assigned to either the opioid-using anesthesia (OUA) or the OSA groups. In the OUA group, remifentanil was administered as an opioid during general anesthesia. In the OSA group, apart from a single dose of 5 μg/kg of alfentanil for tracheal intubation, no other opioids were used. In both groups, a multimodal intravenous non-opioid analgesic regimen was used preferentially in the post-anesthesia care unit (PACU). The primary outcome was the incidence of PONV, assessed by symptoms until the...

Clinical Research Article

October 14, 2024

Comparison of postoperative outcomes after cranial neurosurgery using propofol-based total intravenous anesthesia versus inhalation anesthesia: a nationwide cohort study in South Korea

Tak Kyu Oh, In-Ae Song, Young-Tae Jeon

Korean J Anesthesiol. 2024;77(6):614-622.

Background: We aimed to determine whether propofol-based total intravenous anesthesia (TIVA) is associated with mortality and morbidity following cranial neurosurgery compared with inhalation anesthesia. Methods: This nationwide, retrospective, population-based cohort study included patients who underwent cranial neurosurgery under general anesthesia between January 1, 2016, and December 31, 2021. The two study endpoints were 90-day mortality and postoperative complications. Results: In total, 144,506 adult patients were included: 65,442 patients (45.3%) who received TIVA (TIVA group) and 79,064 (54.7%) who received inhalation anesthesia (inhalation anesthesia group). After propensity score (PS) matching, 97,156 patients (48,578...

Experimental Research Article

October 2, 2024

Dexmedetomidine alleviates CoCl₂-induced hypoxic cellular damage in INS-1 cells by regulating autophagy

Jin Ha Park, Ju Eun Oh, Namo Kim, Young-Lan Kwak

Korean J Anesthesiol. 2024;77(6):623-634.

Background: Ischemia-reperfusion (I/R) injury is inevitable during the perioperative period. The pancreas is susceptible to I/R injury. Autophagy, a self-digestion process, is upregulated during I/R injury and strongly induced by hypoxia. This study aims to determine whether dexmedetomidine can decrease pancreatic β-cell damage by regulating autophagy under hypoxia. Methods: INS-1 rat insulinoma cells were cultured in dexmedetomidine before being exposed to cobalt chloride (CoCl2)-induced hypoxia. Cell viability and the expression of autophagy-related proteins (light chain 3B [LC3B]-II, p62, and ATGs) were assessed. The expression of apoptosis-related proteins (BCL-2 and P-BAD) were also evaluated. CoCl2-treated INS-1 cells were pretreated with the autophagosome formation inhibitor, 3-methyladenine (3-MA), to compare its effects with those...

Achieving relief from nausea and vomiting: from intraoperative to postoperative management Bon-Wook Koo Korean J Anesthesiol. 2024;77(6):573-574. Editorial November 29, 2024 Full text PubReader ePub PDF	Renal implications of pneumoperitoneum in laparoscopic surgery: mechanisms, risk factors, and preventive strategies Gianluca Villa, Marco Fiorentino, Eleonora Cappellini, Sergio Lassola, Silvia De Rosa Korean J Anesthesiol. 2024;77(6):575-586. Review Article April 26, 2024 Full text PubReader ePub PDF PDF(Korean)
Comparison of remimazolam and midazolam for preventing intraoperative nausea and vomiting during cesarean section under spinal anesthesia: a randomized controlled trial Kyuho Lee, Seung Ho Choi, Sangil Kim, Hae Dong Kim, Hyejin Oh, Seung Hyun Kim Korean J Anesthesiol. 2024;77(6):587-595. Clinical Research Article October 8, 2024 Cited By 1 Full text PubReader ePub PDF PDF(Korean)	Reverse tube direction and epistaxis in left nasotracheal intubation: a randomized controlled trial Jun-Young Park, Jihion Yu, Chan-Sik Kim, Taeho Mun, Woo Shik Jeong, Jong Woo Choi, Kichang Lee, Young-Kug Kim Korean J Anesthesiol. 2024;77(6):596-604. Clinical Research Article August 21, 2024 Full text PubReader ePub PDF PDF(Korean)
Effects of opioid-sparing general anesthesia on postoperative nausea and vomiting in laparoscopic gynecological surgery Sun Woo Nam, Sang-Hwan Do, Jung-Won Hwang, Insun Park, Insung Hwang, Hyo-Seok Na Korean J Anesthesiol. 2024;77(6):605-613. Clinical Research Article August 23, 2024 Cited By 1 Full text PubReader ePub PDF PDF(Korean)	Comparison of postoperative outcomes after cranial neurosurgery using propofol-based total intravenous anesthesia versus inhalation anesthesia: a nationwide cohort study in South Korea Tak Kyu Oh, In-Ae Song, Young-Tae Jeon Korean J Anesthesiol. 2024;77(6):614-622. Clinical Research Article October 14, 2024 Full text PubReader ePub PDF PDF(Korean) Supplementary Material
Dexmedetomidine alleviates CoCl₂-induced hypoxic cellular damage in INS-1 cells by regulating autophagy Jin Ha Park, Ju Eun Oh, Namo Kim, Young-Lan Kwak Korean J Anesthesiol. 2024;77(6):623-634. Experimental Research Article October 2, 2024 Full text PubReader ePub PDF PDF(Korean) Supplementary Material	A rare subclavian artery aneurysm potentially misidentified as the internal jugular vein in ultrasound-guided central venous catheterization -a case report- Dae Yun Choi, Daeseok Oh Korean J Anesthesiol. 2024;77(6):635-639. Case Report September 13, 2024 Full text PubReader ePub PDF
Comment on “The incidences of nausea and vomiting after general anesthesia with remimazolam versus sevoflurane: a prospective randomized controlled trial” Murat Izgi, Betul Basaran Korean J Anesthesiol. 2024;77(6):640. Letter to the Editor August 12, 2024 Full text PubReader ePub PDF