Korean Journal of Anesthesiology

The incidences of nausea and vomiting after general anesthesia with remimazolam versus sevoflurane: a prospective randomized controlled trial: Yeong Min Yoo, Jae Hong Park, Ki Hwa Lee, Ah Hyeon Yi, Tae Kyun Kim; Korean J Anesthesiol. 2024;77(4):441-449.

Review Article

August 21, 2023

Tranexamic acid - a promising hemostatic agent with limitations: a narrative review

Dong Joon Kim, Su Yeon Cho, Ki Tae Jung

Korean J Anesthesiol. 2024;77(4):411-422.

Tranexamic acid (TXA) is a synthetic antifibrinolytic agent that has been used for several decades to reduce blood loss during surgery and after trauma. TXA was traditionally used to reduce bleeding in various clinical settings such as menorrhagia, hemophilia, or other bleeding disorder. Numerous studies have demonstrated the efficacy of TXA in reducing blood loss and the need for transfusions. Interest in the potential applications of TXA beyond its traditional use has been growing recently, with studies investigating the use of TXA in postpartum hemorrhage, cardiac surgery, trauma, neurosurgery, and orthopedic surgery. Despite its widespread use and expanding indications, data regarding the safe and appropriate use of TXA is lacking....

Statistical Round

July 30, 2024

Key insights and challenges in noninferiority trials

Boohwi Hong, Dong-Kyu Lee

Korean J Anesthesiol. 2024;77(4):423-431.

Noninferiority clinical trials are crucial for evaluating the effectiveness of new interventions compared to standard interventions. By establishing statistical and clinical comparability, these trials can be conducted to demonstrate that a new intervention is not significantly inferior to the standard intervention. However, selecting appropriate noninferiority margins and study designs are essential to ensuring valid and reliable results. Moreover, employing the Consolidated Standards of Reporting Trials (CONSORT) statement for reporting noninferiority clinical trials enhances the quality and transparency of research findings. This article addresses key considerations and challenges faced by investigators in planning, conducting, and interpreting the results of noninferiority clinical trials.

Clinical Research Article

May 7, 2024

Comparison of remimazolam and desflurane in emergence agitation after general anesthesia for nasal surgery: a prospective randomized controlled study

Sung-Ae Cho, So-min Ahn, Woojin Kwon, Tae-Yun Sung

Korean J Anesthesiol. 2024;77(4):432-440.

Background: Remimazolam is an ultrashort-acting benzodiazepine. Few studies have evaluated the effects of remimazolam-based total intravenous anesthesia (TIVA) on emergence agitation (EA). This study aimed to compare the incidence and severity of EA between TIVA using remimazolam and desflurane. Methods: This prospective randomized controlled study enrolled 76 patients who underwent nasal surgery under general anesthesia. Patients were randomized into two groups of 38 each: desflurane-nitrous oxide (N2O) (DN) and remimazolam-remifentanil (RR) groups. The same protocol was used for each group from induction to emergence, except for the use of different...

Clinical Research Article

April 19, 2024

The incidences of nausea and vomiting after general anesthesia with remimazolam versus sevoflurane: a prospective randomized controlled trial

Yeong Min Yoo, Jae Hong Park, Ki Hwa Lee, Ah Hyeon Yi, Tae Kyun Kim

Korean J Anesthesiol. 2024;77(4):441-449.

Background: Postoperative nausea and vomiting (PONV) refers to nausea and vomiting that occurs within 24-h after surgery or in the post-anesthesia care unit (PACU). Previous studies have reported that the use of remimazolam, a newer benzodiazepine (BDZ) hypnotic, for anesthesia results in less PONV. In this study, we compared the rate of PONV between sevoflurane and remimazolam after general anesthesia. Methods: In this prospective randomized controlled trial, participants aged 20–80 years who underwent elective laparoscopic cholecystectomy or hemicolectomy were randomized to either the remimazolam or sevoflurane group. The primary outcome was...

Clinical Research Article

April 23, 2024

Ultrasound mapping of soft tissue vascular anatomy proximal to the larynx: a prospective cohort study

Alessandro De Cassai, Margherita Iuzzolino, Silvia De Pinto, Giovanni Zecchino, Tommaso Pettenuzzo, et al.

Korean J Anesthesiol. 2024;77(4):450-454.

Background: Bleeding incidents during percutaneous dilatational tracheostomy are concerning, and most cases occur in patients with unrecognized and unanticipated anatomical variations in the vascular anatomy. However, the extent of this variation remains unclear. To address this knowledge gap, our study aimed to comprehensively map laryngeal vascular anatomy in a cohort of adult patients. Methods: Ultrasound assessments of the soft tissue in the neck were performed, spanning from the thyroid cartilage to the third tracheal ring and extending 2 cm laterally on both sidesperformed. We subdivided this area into 12 zones comprising four medial and eight lateral sections. A pre-planned form was used to document the presence of arteries or veins in...

Clinical Research Article

May 7, 2024

Effect of perioperative intravenous ibuprofen versus acetaminophen on postoperative opioid consumption and pain after general anesthesia: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials

Sung Hye Kim, Hyun Kang, In-Jung Jun, Hye Won Park, Byung Hoon Yoo, et al.

Korean J Anesthesiol. 2024;77(4):455-467.

Background: Ibuprofen and acetaminophen are widely used as adjuvant analgesics for postoperative pain. This meta-analysis compared the effects of intravenous (IV) ibuprofen and acetaminophen on postoperative opioid consumption and pain intensity after general anesthesia. Methods: PubMed/MEDLINE, EMBASE, and Cochrane Library databases were searched to identify relevant studies published up to May 2023. Randomized controlled trials comparing the effects of perioperative IV ibuprofen and acetaminophen on postoperative opioid consumption and pain after general anesthesia were included in the meta-analysis and trial sequential analysis (TSA). Results: Eight studies with 494 participants were included. Compared...

Experimental Research Article

April 1, 2024

Damage-associated molecular patterns as a mechanism of sevoflurane-induced neuroinflammation in neonatal rodents

Young-Eun Joe, Ji Hae Jun, Ju Eun Oh, Jeong-Rim Lee

Korean J Anesthesiol. 2024;77(4):468-479.

Background: General anesthesia is inevitable for pediatric patients undergoing surgery, though volatile anesthetic agents may cause neuroinflammation and neurodevelopmental impairment; however, the underlying pathophysiology remains unclear. We aimed to investigate the neuroinflammation mechanism in developing rat brains associated with sevoflurane exposure time, by identifying the specific damage-associated molecular patterns (DAMPs) pathway and evaluating the effects of non-steroidal anti-inflammatory drugs (NSAIDs) in alleviating neuroinflammation. Methods: A three-step experiment was conducted to investigate neuroinflammation induced by sevoflurane. First, the exposure time required for sevoflurane to cause neuroinflammation was determined. Next, the specific pathways of DAMPs involved in neuroinflammation by sevoflurane were identified. Finally, the effects of NSAIDs on sevoflurane-induced neuroinflammation were investigated. The...

Efficacy of remimazolam in reducing postoperative nausea and vomiting: a superior alternative anesthetic for total intravenous anesthesia? Jong Wook Song Korean J Anesthesiol. 2024;77(4):409-410. Editorial July 18, 2024 Full text PubReader ePub PDF	Tranexamic acid - a promising hemostatic agent with limitations: a narrative review Dong Joon Kim, Su Yeon Cho, Ki Tae Jung Korean J Anesthesiol. 2024;77(4):411-422. Review Article August 21, 2023 Cited By 2 Full text PubReader ePub PDF PDF(Korean)
Key insights and challenges in noninferiority trials Boohwi Hong, Dong-Kyu Lee Korean J Anesthesiol. 2024;77(4):423-431. Statistical Round July 30, 2024 Full text PubReader ePub PDF PDF(Korean)	Comparison of remimazolam and desflurane in emergence agitation after general anesthesia for nasal surgery: a prospective randomized controlled study Sung-Ae Cho, So-min Ahn, Woojin Kwon, Tae-Yun Sung Korean J Anesthesiol. 2024;77(4):432-440. Clinical Research Article May 7, 2024 Full text PubReader ePub PDF PDF(Korean)
The incidences of nausea and vomiting after general anesthesia with remimazolam versus sevoflurane: a prospective randomized controlled trial Yeong Min Yoo, Jae Hong Park, Ki Hwa Lee, Ah Hyeon Yi, Tae Kyun Kim Korean J Anesthesiol. 2024;77(4):441-449. Clinical Research Article April 19, 2024 Cited By 2 Full text PubReader ePub PDF PDF(Korean) Supplementary Material	Ultrasound mapping of soft tissue vascular anatomy proximal to the larynx: a prospective cohort study Alessandro De Cassai, Margherita Iuzzolino, Silvia De Pinto, Giovanni Zecchino, Tommaso Pettenuzzo, Annalisa Boscolo, Eugenio Biamonte, Paolo Navalesi, Marina Munari Korean J Anesthesiol. 2024;77(4):450-454. Clinical Research Article April 23, 2024 Full text PubReader ePub PDF PDF(Korean)
Effect of perioperative intravenous ibuprofen versus acetaminophen on postoperative opioid consumption and pain after general anesthesia: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials Sung Hye Kim, Hyun Kang, In-Jung Jun, Hye Won Park, Byung Hoon Yoo, Yun-Hee Lim, Kye-Min Kim Korean J Anesthesiol. 2024;77(4):455-467. Clinical Research Article May 7, 2024 Full text PubReader ePub PDF PDF(Korean) Supplementary Material	Damage-associated molecular patterns as a mechanism of sevoflurane-induced neuroinflammation in neonatal rodents Young-Eun Joe, Ji Hae Jun, Ju Eun Oh, Jeong-Rim Lee Korean J Anesthesiol. 2024;77(4):468-479. Experimental Research Article April 1, 2024 Cited By 1 Full text PubReader ePub PDF PDF(Korean) Supplementary Material
Retro superior costotransverse ligament space block as an effective analgesia after laparoscopic gastrectomy -a case report-[commentary-article] Youngin Lee, Seunguk Bang, Jihyun Chung, Jookyoung Moon Korean J Anesthesiol. 2024;77(4):480-483. Case Report April 15, 2024 Full text PubReader ePub PDF	The effects of sugammadex on isolated human internal mammary artery and saphenous vein rings Mert C. Ongun, Bahar Oc, Mehmet Oc, Hulagu Bariskaner Korean J Anesthesiol. 2024;77(4):484-485. Letter to the Editor May 22, 2024 Full text PubReader ePub PDF
Response to "Comment on Comparison of the pericapsular nerve group block with the intra-articular and quadratus lumborum blocks in primary total hip arthroplasty: a randomized controlled trial" Tayfun Et, Muhammet Korkusuz Korean J Anesthesiol. 2024;77(4):485-487. Letter to the Editor April 25, 2024 Full text PubReader ePub PDF	Assessment of fluid infusion rate using a pulse oximeter: a pilot study Yeiheum Park, Sungho Moon Korean J Anesthesiol. 2024;77(4):487-488. Letter to the Editor April 24, 2024 Full text PubReader ePub PDF Supplementary Material
Venous air emboli during esophagoscopy confirmed by computed tomographic pulmonary angiography -a case report- Thadakorn Tantisarasart, Thara Tantichamnankul, Chanatthee Kitsiripant, Panjai Choochuen Korean J Anesthesiol. 2024;77(4):489-489. Corrects: Korean J Anesthesiol 2024 4; 77(2): 278 Corrigendum June 25, 2024 Full text PubReader ePub PDF