Korean Journal of Anesthesiology

Effect of remimazolam on postoperative delirium and cognitive function in adults undergoing general anesthesia or procedural sedation: a meta-analysis of randomized controlled trials: Ji-In Park, Hyo-Seok Na, Ji-Na Kim, Jung-Hee Ryu, Howon Jang, et al.; Korean J Anesthesiol. 2025;78(2):118-128.

Review Article

December 16, 2024

A comprehensive analysis of propofol abuse, addiction and neuropharmacological aspects: an updated review

Tayfun Uzbay, Andleeb Shahzadi

Korean J Anesthesiol. 2025;78(2):91-104.

This review aims to assess the existing studies on propofol, a relatively new intravenous anesthetic, related to its abuse and addictive potential and to explain the neurobiological and neuropharmacological aspects of propofol addiction. Several neurobiological factors related to complex processes in the brain influence propofol abuse and addiction. In this review, we assessed the literature regarding propofol abuse and addiction, including both experimental and clinical studies. We selected articles from animal studies, case reports, clinical trials, meta-analyses, narrative reviews, and systematic reviews to extract all relevant crucial quantitative data with a measure of neurobiological and neuropharmacological aspects. Thus, the main goal of this study was to investigate the current literature...

Review Article

January 15, 2025

Extended reality in anesthesia: a narrative review

Sung Hee Han, Kristen L Kiroff, Sakura Kinjo

Korean J Anesthesiol. 2025;78(2):105-117.

The application of extended reality (XR) technology is rapidly expanding in the medical field, including anesthesia. This review aims to introduce the current literature on XR utilization to help anesthesiologists adopt this technology in education and clinical practice. XR is useful for both knowledge acquisition and skill training in a wide range of settings, from students to medical professionals. One of its major benefits is harm reduction through simulation scenarios that allow for immersion in clinical situations and opportunities to practice procedures and tasks. These scenarios often involve both technical and non-technical skills, enabling clinicians to enhance their capabilities without risking patient safety. In clinical settings, XR can also be...

Clinical Research Article

January 3, 2025

Effect of remimazolam on postoperative delirium and cognitive function in adults undergoing general anesthesia or procedural sedation: a meta-analysis of randomized controlled trials

Ji-In Park, Hyo-Seok Na, Ji-Na Kim, Jung-Hee Ryu, Howon Jang, et al.

Korean J Anesthesiol. 2025;78(2):118-128.

Background: Remimazolam is a novel short-acting benzodiazepine. This study compared the effects of remimazolam and propofol on cognitive function in adult patients after surgery or other procedures. Methods: We searched electronic databases, including PubMed, Embase, CENTRAL, Web of Science, and Scopus, for relevant studies. The primary outcome was the proportion of participants who experienced delirium or impaired cognitive function postoperatively. Secondary outcomes included the incidence of hypotension, bradycardia, and postoperative nausea and vomiting. We estimated the odds ratios (OR) and mean differences (MD) with 95% CIs using a random-effects model. Results: In...

Clinical Research Article

December 20, 2024

Post-anesthesia care unit delirium in children with moyamoya disease undergoing indirect revascularization: incidence and risk factors

Kun Liu, Lin He

Korean J Anesthesiol. 2025;78(2):129-138.

Background: Delirium in the post-anesthesia care unit (PACU) may be associated with worse outcomes in children with moyamoya disease (MMD). This retrospective study aimed to describe the prevalence of PACU delirium in children with MMD and investigate its risk factors. Methods: Patients with MMD aged < 15 years who underwent indirect revascularization between January 2014 and October 2023 were included in this study. Delirium was assessed using the Pediatric Anesthesia Emergence Delirium Scale. Potential risk factors for PACU delirium were evaluated using multivariate logistic regression. Results: PACU delirium occurred in 245 (33%)...

Clinical Research Article

January 3, 2025

Hypotension after induction of anesthesia with remimazolam or etomidate: a non-inferiority randomized controlled trial in patients undergoing coronary artery bypass grafting

Jeong-Jin Min, Eun Jung Oh, Hyun Ji Hwang, Sungwoo Jo, Hyunsung Cho, et al.

Korean J Anesthesiol. 2025;78(2):139-147.

Background: Remimazolam is a novel ultra-short-acting benzodiazepine known for its hemodynamic stability over propofol. However, its hemodynamic effects compared to those of etomidate are not well established. This study aimed to determine whether the use of remimazolam is non-inferior to etomidate with regard to the occurrence of post-induction hypotension in patients undergoing coronary artery bypass grafting. Methods: Patients were randomly assigned to either the remimazolam group (6 mg/kg/h) or the etomidate group (0.3 mg/kg) for induction of anesthesia. Anesthetic depth was adjusted based on the bispectral index. Primary outcome was the...

Clinical Research Article

January 23, 2025

Effect of remimazolam on intraoperative hemodynamic stability in patients undergoing cerebrovascular bypass surgery: a prospective randomized controlled trial

Chang-Hoon Koo, Si Un Lee, Hyeong-Geun Kim, Soowon Lee, Yu Kyung Bae, et al.

Korean J Anesthesiol. 2025;78(2):148-158.

Background: Maintenance of stable blood pressure (BP) during cerebrovascular bypass surgery is crucial to prevent cerebral ischemia. We compared the effect of remimazolam anesthesia with that of propofol-induced and desflurane-maintained anesthesia on intraoperative hemodynamic stability and the need for vasoactive agents in patients undergoing cerebrovascular bypass surgery. Methods: Sixty-five patients were randomized into remimazolam (n = 31, remimazolam-based intravenous anesthesia) and control groups (n = 34, propofol-induced and desflurane-maintained anesthesia). The primary outcome was the occurrence of intraoperative hypotension. The secondary outcomes included hypotension duration, lowest mean BP (MBP), generalized average...

Clinical Research Article

January 21, 2025

Analgesic efficacy of the external oblique intercostal fascial plane block on postoperative acute pain in laparoscopic sleeve gastrectomy: a randomized controlled trial

Elif Sarikaya Ozel, Cengiz Kaya, Esra Turunc, Yasemin B. Ustun, Halil Cebeci, et al.

Korean J Anesthesiol. 2025;78(2):159-170.

Background: Laparoscopic sleeve gastrectomy (LSG) causes significant postoperative pain, necessitating effective multimodal analgesia strategies. This study evaluated the efficacy of the external oblique intercostal block (EOIB) in this context. Methods: This prospective, randomized, controlled, single-blind study conducted between April and December 2023 included 60 patients who underwent LSG. Patients were divided into the EOIB (30 ml 0.25% bupivacaine/side) and control (no block) groups. The primary outcome was the cumulative intravenous morphine milligram equivalent (MME) consumption in the first 24 h postoperatively. Secondary outcomes included 12-h MME consumption, pain scores, intraoperative remifentanil...

Remimazolam – expectations and concerns Jae Hoon Lee Korean J Anesthesiol. 2025;78(2):89-90. Editorial March 21, 2025 Full text PubReader ePub PDF	A comprehensive analysis of propofol abuse, addiction and neuropharmacological aspects: an updated review Tayfun Uzbay, Andleeb Shahzadi Korean J Anesthesiol. 2025;78(2):91-104. Review Article December 16, 2024 Cited By 1 Full text PubReader ePub PDF
Extended reality in anesthesia: a narrative review Sung Hee Han, Kristen L Kiroff, Sakura Kinjo Korean J Anesthesiol. 2025;78(2):105-117. Review Article January 15, 2025 Full text PubReader ePub PDF	Effect of remimazolam on postoperative delirium and cognitive function in adults undergoing general anesthesia or procedural sedation: a meta-analysis of randomized controlled trials Ji-In Park, Hyo-Seok Na, Ji-Na Kim, Jung-Hee Ryu, Howon Jang, Hyun-Jung Shin Korean J Anesthesiol. 2025;78(2):118-128. Clinical Research Article January 3, 2025 Cited By 3 Full text PubReader ePub PDF Supplementary Material
Post-anesthesia care unit delirium in children with moyamoya disease undergoing indirect revascularization: incidence and risk factors Kun Liu, Lin He Korean J Anesthesiol. 2025;78(2):129-138. Clinical Research Article December 20, 2024 Full text PubReader ePub PDF Supplementary Material	Hypotension after induction of anesthesia with remimazolam or etomidate: a non-inferiority randomized controlled trial in patients undergoing coronary artery bypass grafting [corrected-article] Jeong-Jin Min, Eun Jung Oh, Hyun Ji Hwang, Sungwoo Jo, Hyunsung Cho, Chungsu Kim, Jong-Hwan Lee Korean J Anesthesiol. 2025;78(2):139-147.Correction in: https://doi.org/10.4097/kja.24537.e1 Clinical Research Article January 3, 2025 Cited By 1 Full text PubReader ePub PDF
Effect of remimazolam on intraoperative hemodynamic stability in patients undergoing cerebrovascular bypass surgery: a prospective randomized controlled trial Chang-Hoon Koo, Si Un Lee, Hyeong-Geun Kim, Soowon Lee, Yu Kyung Bae, Ah-Young Oh, Young-Tae Jeon, Jung-Hee Ryu Korean J Anesthesiol. 2025;78(2):148-158. Clinical Research Article January 23, 2025 Cited By 1 Full text PubReader ePub PDF	Analgesic efficacy of the external oblique intercostal fascial plane block on postoperative acute pain in laparoscopic sleeve gastrectomy: a randomized controlled trial Elif Sarikaya Ozel, Cengiz Kaya, Esra Turunc, Yasemin B. Ustun, Halil Cebeci, Burhan Dost Korean J Anesthesiol. 2025;78(2):159-170. Clinical Research Article January 21, 2025 Cited By 1 Full text PubReader ePub PDF Supplementary Material
Modified approach to external oblique intercostal block: a proof-of-concept pilot case series and anatomical evaluation -a case series- Takashi Fujino, Koichiro Ichimura, Hidaka Anetai, Izumi Kawagoe Korean J Anesthesiol. 2025;78(2):171-176. Case Report January 20, 2025 Full text PubReader ePub PDF	The emerging role of fluoroscopy-guided high-intensity focused ultrasound ablation in lumbar facet joint pain management Wasimul Hoda, Khushboo Pandey Korean J Anesthesiol. 2025;78(2):177-178. Letter to the Editor December 26, 2024 Full text PubReader ePub PDF
Comment on “Cardiac arrest due to coronary vasospasm after sugammadex administration -a case report-” Balaji Vaithialingam Korean J Anesthesiol. 2025;78(2):178-179. Letter to the Editor January 8, 2025 Full text PubReader ePub PDF