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Korean J Anesthesiol > Epub ahead of print
DOI: https://doi.org/10.4097/kja.21569    [Epub ahead of print]
Published online June 28, 2022.
The effect of equipotent dose of propofol and sevoflurane on endoplasmic reticulum stress during breast cancer surgery
Chung-Sik Oh1,3, Seung Wan Hong1, Sarah Park1, Yubi Kwon1, Seong-Hyop Kim1,2,3
1Department of Anesthesiology and Pain Medicine, Konkuk University School of Medicine, Konkuk University Medical Center, Seoul, Korea
2Department of Infection and Immunology, Konkuk University School of Medicine, Seoul, Korea
3Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea
Corresponding author:  Seong-Hyop Kim, Tel: +82-2-2030-5454, Fax: +82-2-2030-5449, 
Email: yshkim75@daum.net
Received: 29 December 2021   • Revised: 29 May 2022   • Accepted: 27 June 2022
Numerous studies suggest a benefit of the use of intravenous propofol over inhalational volatile anesthetic. The objective of this study was to compare the changes in endoplasmic reticulum (ER) stress of cancer cells and lymphocytes after propofol- or sevoflurane-based anesthesia during breast cancer surgery.
A total of 53 patients having breast cancer surgery were randomized and analyzed (28 for propofol, 25 for sevoflurane). Blood samples were obtained immediately before anesthesia induction, and 1 and 24 hours postoperatively. Human breast cancer cell lines were cultured and then treated with patients’ plasma and the frequency of C/EBP homologous protein (CHOP) on cancer cell lines and lymphocytes were measured. The neutrophil-to-lymphocyte ratio in plasma was also evaluated in both groups.
The expressions of CHOP of breast cancer cell lines in both groups did not show significant intergroup differences between the two groups (P = 0.108). However, they significantly decreased over time (P = 0.027). The expressions of CHOP on lymphocytes were comparable between the two groups (P = 0.485), and the neutrophil to lymphocyte ratio did not significantly differ between the two groups (P = 0.501).
Propofol-based anesthesia did not induce higher ER stress rather than sevoflurane-based anesthesia during breast cancer surgery. The types of anesthetics during breast cancer surgery did not have different effect on ER stress of cancer cells.
Key Words: Endoplasmic reticulum, Propofol, Sevoflurane, Breast Cancer, Apoptosis
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