Korean J Anesthesiol Search

CLOSE


Korean Journal of Anesthesiology 2009;57(1):88-95.
DOI: https://doi.org/10.4097/kjae.2009.57.1.88   
Effect of amnion derived stem cells on inflammatory response in endotoxemic rats.
Ji Young Yoon, Hae Kyu Kim
Department of Anesthesiology and Pain Medicine, School of Medicine, Pusan National University, Busan, Korea. hakykim@pusan.ac.kr
Abstract
BACKGROUND
Systemic inflammatory response syndrome (SIRS) and sepsis are one among the most common causes of death in intensive care units. Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) increase during SIRS and sepsis. Recent studies have demonstrated that amnion derived stem cells have anti-inflammatory effects, low immunogenicity and pluripotency. In addition, there is little ethical objection to the use of amnion derived stem cells. Here, the author presents the first study demonstrating the therapeutic potential for the use of amnion derived stem cells in a rat model of SIRS and sepsis. METHODS: Amnion derived stem cells were isolated from amnion obtained from an uncomplicated Cesarean section and cultured. SIRS and sepsis were induced in rats by lipopolysacchride (15 mg/kg, LPS), and amnion derived stem cells were then transplanted intravenously. The heart rate, mean arterial pressure and the concentration of TNF-alpha, IL-6 and IL-10 were assessed at baseline and 2 hours and 4 hours after procedure. RESULTS: The changes of heart rate and mean arterial pressure were reduced in the amnion derived stem cells transplanted group. In addition, increases in the plasma concentration of TNF-alpha, IL-6 and IL-10 were attenuated in the amnion derived stem cells transplanted group. CONCLUSIONS: This study demonstrated that amnion derived stem cells attenuate inflammatory response during SIRS and sepsis. Transplantation of amnion derived stem cells can be a novel cell based therapeutic strategy for SIRS and sepsis.
Key Words: Amnion; IL-6; IL-10; Sepsis; Stem cell; TNF-alpha


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
(서울특별시 마포구 마포대로 109 롯데캐슬 프레지던트 101동 3503호)
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                
Business Name: Korean Society of Anesthesiologists (대한마취통증의학회)
Business Registration: 106-82-07194
Representative: Jun Heum Yon (연준흠)

Copyright © 2024 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next