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Korean Journal of Anesthesiology 2005;48(6):587-591.
DOI: https://doi.org/10.4097/kjae.2005.48.6.587   
Effects of a Combination of Nicardipine and Alfentanil on Hemodynamic Response after Endotracheal Intubation.
Chang Mo Kim, Sung Tae Jeong, Seok Jai Kim, Hong Beom Bae, Jeong Il Choi, Seong Wook Jeong, Sung Su Chung, Kyung Yeon Yoo, Chang Young Jeong, Myung Ha Yoon
1Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University, Gwangju, Korea. mhyoon@chonnam.ac.kr
2Department of Anesthesiology School of Dentistry, Chonnam National University, Gwangju, Korea.
The present study was designed to examine the effect of a combination of nicardipine and low dose alfentanil on hemodynamic response following endotracheal intubation.
Thirty patients (20-65 yr) were assigned randomly to receive nicardipine (N: 20microgram/kg) or a combination of nicardipine and low dose of alfentanil (NA: nicardipine 10microgram/kg and alfentanil 5microgram/kg). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at 1, 2 min after anesthetic induction, and every minute for 5 min after intubation.
The magnitude of increases in SBP and DBP were non-significantly smaller in the NA group than in the N group, and increase in HR were significantly lower in the NA group.
These results indicate that the nicardipine with alfentanil combination was more effective than nicardipine alone at attenuating blood pressure and heart rate increases following intubation.
Key Words: alfentanil; nicardipine; intubation; systolic blood pressure; diastolic blood pressure; heart rate


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