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Korean J Anesthesiol > Volume 53(3); 2007 > Article
Korean Journal of Anesthesiology 2007;53(3):344-349.
DOI: https://doi.org/10.4097/kjae.2007.53.3.344   
Effectiveness of Ondansetron and Midazolam in the Prevention of PONV after Thyroidectomy.
Jae Hyun Ha, Kyung Hwa Kwak, Jeong Won Seo, Su Hyun Lee, Sung Sik Park, Woon Ei Baek
Department of Anesthesiology and Pain Medicine, Kyungpook National University School of Medicine, Deagu, Korea. hwakkh@hotmail.com
Abstract
BACKGROUND
The purpose of this study was to investigate the effectiveness of ondansetron and midazolam in the prevention of PONV after thyroidectomy.
METHODS
One hundred nineteen women undergoing thyroidectomy under general anesthesia were randomized to receive midazolam 0.075 mg/kg (Group M, n = 41), ondansetron 4 mg (Group O, n = 39), or normal saline 10 ml (Group C, n = 39) intravenously. The incidence and severity of nausea, vomiting, and pain were assessed as 6 and 24 h after the end of surgery.
RESULTS
The incidence of PONV was 34% in Group M, 46% in Group O, and 64% in Group C, which showed a significant difference between Group C and Group M, but not Group O. However, there were no significant differences between groups in pain scores and the incidence of sedation.
CONCLUSIONS
We recommend the use of midazolam as an effective antiemetic after thyroidectomy.
Key Words: antiemetic; ondansetron; midazolam; postoperative nausea and vomiting (PONV); thyroidectomy
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