| Effect of Midazolam upon the Prevention of Nausea and Vomiting after Middle Ear Surgery. |
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Jae Sik Jung, Young Hun Jeon |
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Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, Korea. jeon68@knu.ac.kr |
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| Abstract |
BACKGROUND
Midazolam has been reported to decrease postoperative nausea and vomiting (PONV). We studied the antiemetic effect of midazolam after middle ear surgery.
METHODS
In this prospective, randomized, double-blind, placebo-controlled study, 90 healthy patients were scheduled for middle ear surgery (tympanomastoidectomy and tympanoplasty). Patients were randomly divided into two groups; Midazolam 0.075 mg/kg (n = 45) or normal saline (n = 45) was administered after induction of anesthesia. The incidence of PONV, metoclopramide and ketorolac usage, pain, sedation, and other side effects were assessed at 6, 24 h after the operation.
RESULTS
The incidences of PONV were 15 (33%) in midazolam group and 27 (60%) in placebo group during 24 h postoperatively. The incidence of PONV in midazolam group was significantly lower than that in placebo group (P < 0.05). There were no significant differences between groups in adverse events.
CONCLUSIONS
Midazolam 0.075 mg/kg was effective for preventing PONV after middle ear surgery without significant adverse effects. |
| Key Words:
midazolam; middle ear surgery; postoperative nausea and vomiting (PONV) |
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