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Korean J Anesthesiol > Volume 52(5); 2007 > Article
Korean Journal of Anesthesiology 2007;52(5):550-555.
DOI: https://doi.org/10.4097/kjae.2007.52.5.550   
Effect of Midazolam upon the Prevention of Nausea and Vomiting after Middle Ear Surgery.
Jae Sik Jung, Young Hun Jeon
Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, Korea. jeon68@knu.ac.kr
Abstract
BACKGROUND
Midazolam has been reported to decrease postoperative nausea and vomiting (PONV). We studied the antiemetic effect of midazolam after middle ear surgery.
METHODS
In this prospective, randomized, double-blind, placebo-controlled study, 90 healthy patients were scheduled for middle ear surgery (tympanomastoidectomy and tympanoplasty). Patients were randomly divided into two groups; Midazolam 0.075 mg/kg (n = 45) or normal saline (n = 45) was administered after induction of anesthesia. The incidence of PONV, metoclopramide and ketorolac usage, pain, sedation, and other side effects were assessed at 6, 24 h after the operation.
RESULTS
The incidences of PONV were 15 (33%) in midazolam group and 27 (60%) in placebo group during 24 h postoperatively. The incidence of PONV in midazolam group was significantly lower than that in placebo group (P < 0.05). There were no significant differences between groups in adverse events.
CONCLUSIONS
Midazolam 0.075 mg/kg was effective for preventing PONV after middle ear surgery without significant adverse effects.
Key Words: midazolam; middle ear surgery; postoperative nausea and vomiting (PONV)
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