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Korean J Anesthesiol > Volume 54(3); 2008 > Article
Korean Journal of Anesthesiology 2008;54(3):S35-S39.
DOI: https://doi.org/10.4097/kjae.2008.54.3.S35   
Antinociceptive Effect of Intraperitoneally Administered 5,5-dimethyl-1-pyrroline N-oxide on Formalin Induced Nociception in Rats.
Woo suk Chung, Young gwon Go, Won hyung Lee
Department of Anesthesiology and Pain Medicine, Research Institute for Medicial Sciences,Chungnam National University College of Medicine, Daejeon, Korea. whlee@cnu.ac.kr
Abstract
BACKGROUND
Reactive oxygen species (ROS) is known to be involved in chronic and persistent pain.By using the ROS scavenger 5,5-dimethyl-1-pyrroline N-oxide (DMPO), we studied the effects of ROS on formalin-induced nociception in rats.
METHODS
5% formalin was injected in the left hind paw after intraperitoneal injection of saline or various doses of DMPO (10 mg/kg, 30 mg/kg, 100 mg/kg).Number of flinches was measured in a 5 minute interval for 1 hour.
RESULTS
Formalin injected into the left hind paw induced a biphasic nociceptive behaviour. Intraperitoneal injection of DMPO diminished nociceptive behaviors dose-dependently during phase 2 but not phase 1.
CONCLUSIONS
ROS might be involved in central sensitization and DMPO, a ROS scavenger, posses antinociceptive property in rats subjected to formalin induced hyperalgesia.
Key Words: DMPO; formalin test; ROS
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