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Korean Journal of Anesthesiology 2005;49(4):472-476.
DOI: https://doi.org/10.4097/kjae.2005.49.4.472   
The Comparison of Co-administration of Alfentanil-Propofol with Propofol in Insertion of Laryngeal Mask Airway.
Hyun Jung Kim, Jae Ik Lee, Jae Myeong Lee, Jae Hang Shim, Woo Jae Jeon, Jong Hoon Yeom, Woo Jong Shin, Kyoung Hun Kim, Sang Yoon Cho
1Department of Anesthesiology and Pain Medicine, College of Medicine, Hanyang University, Seoul, Korea. chosy@hanyang.ac.kr
2Department of Anesthesiology and Pain Medicine, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea.
We performed a prospective, randomized, controlled trial to compare the quality, hemodynamic response, and recovery index of laryngeal mask airway (LMA) insertion after either propofol alone or co-administration of alfentanil-propofol anesthesia.
Sixty patients (ASA 1 or 2, 17-63 years) were randomly allocated to control and experimental group. Control group(Group I) was received placebo (saline), experimental groups were received alfentanil 10microgram/kg (Group II), 20microgram/kg (Group III), 30microgram/kg (Group IV).
Loss of consciousness and LMA insertion were more rapid in patients with alfentanil 30 microgram/kg group than control group (P<0.05). In alfentanil 20microgram/kg group, loss of consciousness was more rapid than control group. Also, there were significant differences in propofol induction dose, effect site concentration on induction, and propofol maintenance dose between control and experimental group (P<0.05).
We conclude that co-adminstration of alfentanil-propofol, especially 30microgram/kg group, compares favorably with propofol alone, although LMA removal time is prolonged.
Key Words: alfentanil; laryngeal mask airway; propofol
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