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Korean J Anesthesiol > Volume 51(3); 2006 > Article
Korean Journal of Anesthesiology 2006;51(3):330-334.
DOI: https://doi.org/10.4097/kjae.2006.51.3.330   
Median Effective Concentration (EC(50)) of Propofol for Insertion of Laryngeal Mask Airway and Laryngeal Tube in Children.
Hye Jin Park, Tae Gyoon Yoon, Chong Sung Kim, Seong Deok Kim, Hee Soo Kim
1Department of Anesthesiology, College of Medicine, Eulji University, Seoul, Korea. dami0605@snu.ac.kr
2Department of Anesthesiology, Seoul National University College of Medicine, Seoul, Korea.
Abstract
BACKGROUND
The median effective concentration, EC(50), for the supraglottic airway (predicted plasma concentration equilibrated with the effect site at which supraglottic airway insertion is successful in 50% of patients) of propofol in children was not known. The aim of this study was to determine the EC(50) with a target-controlled infusion of propofol to insert a classic laryngeal mask airway (LMA) and laryngeal tube (LT) in pediatric patients.
METHODS
Pediatric patients scheduled for urologic, orthopedic, or plastic surgery lasting less than 2 hr under general anesthesia were enrolled in this study. The patients were divided into two groups in a randomized, double blind manner. After applying a standard cardiorespiratory monitor, anesthesia was carried out with a target-controlled infusion (TCI) using the stelpump program. The initial target concentration of propofol was 5microgram/ml, and in accordance with Dixon's up-and-down, the propofol concentration for consecutive patients in each group was varied with increments or decrements of 0.2microgram/ml based on the previous patient insertion result.
RESULTS
The EC(50) of propofol required to insert a LMA and LT was 5.5+/-0.2microgram/ml and 5.6+/-0.2microgram/ml, respectively.
CONCLUSIONS
The EC50 of propofol is similar for LMA and LT.
Key Words: anesthesia intravenous; child; laryngeal mask airway; propofol
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