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Korean Journal of Anesthesiology 2003;44(1):12-17.
DOI: https://doi.org/10.4097/kjae.2003.44.1.12   
A Comparison of the Effects of Different Doses of Butorphanol Administered in Conjunction with Ketorolac in Intravenous Patient Controlled Analgesia.
In Kyu Kim, Sung Jin Park, In Young Oh, Chang Kil Park, Tae Yop Kim, Sung Ho Lee, Myung Kun Shin
1Department of Anesthesiology, Samsung Hospital, Sungkyunkwan University School of Medicine, Masan, Korea. inyoungoh@hanmail.net
2Department of Anesthesiology, Eulji University School of Medicine, Daejeon, Korea.
We designed a randomized study to assess the analgesic efficacy, side effects, and satisfaction score among different doses of butorphanol by using intravenous patient controlled analgesia (IVPCA) for pain relief following a cesarean section.
Sixty women who received a cesarean section were randomly divided into 3 groups. Each group received butorphanol 3 mg (Group 1), 5 mg (Group 2) or 7 mg (Group 3) with ketorolac 150 mg. Butorphanol and ketorolac were administerd by a two day infusor at the rate of 2 ml/hr. Assessments for pain with NRS, and side effects were evaluated in the recovery room, at 3 hr, 6 hr, 12 hr, 24 hr and 48 hr after the operation. A patient satisfaction score was evaluated at 24 hr and 48 hr after the operation.
Pain score at 3 hr after the operation was significantly lower ine Group 2 than Group 1 (P<0.05), at 6 hr and 12 hr after the operation was significantly lower in Group 2 and Group 3 than Group 1 (P<0.05). However, there was no significant difference between Group 2 and Group 3. Patient satisfaction score at 24 hr and 48 hr after the operation did not show any significant difference among the three groups. One patient in Group 2 revealed sedation over 3 on a 4-point scale at 3 hr after the operation, but there was no significant difference among the three groups.
The above results suggested that both butorphanol 5 mg and 7 mg with ketorolac 150 mg via IVPCA were an effective dosage for postoperative pain control during two days after a cesarean section without any significant side effects.
Key Words: Butorphanol; cesarean section; ketorolac; postoperative analgesia


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