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Korean J Anesthesiol > Volume 38(6); 2000 > Article
Korean Journal of Anesthesiology 2000;38(6):1062-1067.
DOI: https://doi.org/10.4097/kjae.2000.38.6.1062   
The Role of the Glutamate Receptor in the Transient Focal Cerebral Ischemia in Rats.
Chang Hee Chae, Hae Kyu Kim, Kyung Hoon Kim, Seong Wan Baik, Inn Se Kim
Department of Anesthesiology, College of Medicine, Pusan National University, Pusan, Korea.
Abstract
BACKGROUND
To investigate the role of glutamate in the transient focal cerebral ischemia, a reversible middle cerebral artery occlusion model was induced in 25 male Sprague-Dawley rats.
METHODS
Triphenyltetrazolium chloride (TTC) stain was used for evaluation of the changes of infarction ratio in MK-801 (0.3, 1.0, 3.0 mg/kg) or pentylenetetrazole (50 mg/kg) treated groups.
RESULT
The infarction ratio at 48 hours after 2 hour transient focal brain ischemia was 39.2 +/- 13.2% in control group and 23.8 +/- 4.2, 27.0 +/- 8.9, and 12.8 +/- 4.4% in MK-801 (0.3, 1.0, 3.0 mg/kg) groups. In the pentylenetetrazole (PTZ) group, the infarction ratio was 32.6 +/- 6.7%.
CONCLUSIONS
The non-specific glutamate receptor antagonist, MK-801, showed a trend toward dose-dependent improvement, but the PTZ group showed no improvement. From these results, it suggested that glutamate might be partly involved in the mechanisms of ischemia-induced neuronal damage.
Key Words: Animal: rats; Brain: edema; middle cerebral artery occlusion; Pharmacology: penty lenetetrazole; MK-801
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