Korean J Anesthesiol Search


Korean Journal of Anesthesiology 2000;39(3):309-313.
DOI: https://doi.org/10.4097/kjae.2000.39.3.309   
Effects of Etomidate, Propofol and Thiopental Sodium on Intraocular Pressure during the Induction of Anesthesia.
Sang Hyun Kim, Sun Hak Lee, Se Hong Shim, Jin Soo Kim, Soo Dal Kwak, Chun Sook Kim, Ki Ryang Ahn
Department of Anesthesiology, College of Medicine, Soon Chun Hyang University, Seoul, Korea.
During ophthalmologic surgery, a variety of anesthetic induction techniques are used in an attempt to prevent the rise of intraocular pressure (IOP). This study compared the effects of etomidate, a new intravenous anesthetic agent, on the changes in IOP with those of thiopental sodium and propofol.
Forty-five patients were randomly allocated and divided into three groups to be injected intravenously with etomidate 0.2-0.3 mg/kg (E-group, n = 15), propofol 2-3 mg/kg (P-group, n = 15) or thiopental sodium 4-5 mg/kg (T-group, n = 15). Systolic arterial pressure (SAP), heart rate (HR) and intraocular pressure (IOP) were measured at 1, 2 and 3 minutes after the administration of the induction agents. During the induction of anesthesia, the incidence of IV injection pain, myoclonus, hiccup and a decrease in SAP of more than 30% were investigated.
At 1, 2 and 3 min following the induction of anesthesia, the SAP in the P-Group decreased significantly more than that in the other two groups (P < 0.05). After the induction, heart rate in the T-Group increased significantly more than that in the other two groups (P < 0.05). The three intravenous agents induced a significant decrease in IOP after an injection (P < 0.05). Comparing the three groups, the IOP in the E- and P-Group decreased significantly more than that in the T-Group (P < 0.05).
Etomidate may be used as a choice of intravenous induction agent to reduce intraocular pressure in ophthalmologic operations especially in an emergency situation, geriatric and hypovolemic patients.
Key Words: Anesthetics, intravenous: etomidate; propofol; thiopental sodium; Mointoring: intraocular pressure


Browse all articles >

Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2024 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next