Korean J Anesthesiol Search

CLOSE


Korean J Anesthesiol > Volume 40(2); 2001 > Article
Korean Journal of Anesthesiology 2001;40(2):238-243.
DOI: https://doi.org/10.4097/kjae.2001.40.2.238   
Neuroprotective Effects of Propofol, Ketamine and Propofol-ketamine after Transient Forebrain Ischemia in the Rat.
Jae Young Kwon, Jae Hyu Jeon, Kyoo Sub Chung, Inn Se Kim, Seong Wan Baik, Hae Kyu Kim
Department of Anesthesiology, College of Medicine, Pusan National University, Pusan, Korea.
Abstract
BACKGROUND
Intravenous anesthetics such as propofol and ketamine have been known to have neuroprotective effects. However, the combination of these drug is not known. This study was conducted to determine the neuroprotective effects of propofol, ketamine or both after transient forebrain ischemia.
METHODS
Twenty Sprague-Dawley rats (250-300 gm) were used. Anesthesia was induced with 4% isoflurane in oxygen and then maintained with 1 - 2% isoflurane in oxygen. Ischemic injury was induced by 10 minutes of both common carotid artery ligation and hypotension (MAP < 50 mmHg). All rats were randomly divided into four groups: group I; control group; group II; ketamine 10 mg/kg was administered 10 minutes before injury; group III; propofol (1 mg/kg/min) was administered until EEG isoelectricity; and group IV; ketamine 10 mg/kg and propofol 1 mg/kg/min was administered. The Rectal temperature was maintained at 38oC. After forebrain ischemia, neurologic scores were estimated at 1 hr, 2 hrs, 1 day and 2 days after recovery. The brain was removed 3 days after and stained with H-E stain.
RESULTS
Neurologic and histologic scores of group II, III, IV were significantly lower than that of group I. However, there were no significant difference between group II, III and IV.
CONCLUSIONS
Ketamine and propofol have neuroprotective effects in transient forebrain ischemia in rats. However, the combination of propofol and ketamine did not show any synergistic or additive effects.
Key Words: Animal: rats; Anesthetics, intravenous: ketamine; propofol; Brain: ischemic injury
TOOLS
Share :
Facebook Twitter Linked In Line it
METRICS Graph View
  • 1 Crossref
  •    
  • 924 View
  • 3 Download


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2023 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next