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Korean J Anesthesiol > Volume 41(1); 2001 > Article
Korean Journal of Anesthesiology 2001;41(1):47-51.
DOI: https://doi.org/10.4097/kjae.2001.41.1.47   
Differential Analgesic and Adverse Effects of 0.125% Bupivacaine vs. Ropivacaine Coadministered Epidurally with Morphine.
Hyeon Jeong Yang, Yoon Sung Kim, Min Gu Kim, Hyeon Ju Kil, Myong Hee Kim
Department of Anesthesiology, College of Medicine, Pocheon Jungmun University, Songnam, Korea.
This study aimed to compare analgesic efficacy and occurance of motor block and other side effects of a 48 hr postoperative continuous epidural infusion of 0.125% bupivacaine or ropivacaine with morphine.
Forty patients undergoing a Cesarean section were allocated randomly into two groups. Both groups received an epidural injection of 2.0% lidocaine 18 20 ml and 0.5% bupivacaine 2 5 ml with fentanyl 50microgram 20 minutes before surgical incision and received 2 mg of epidural morphine by bolus 40 minutes after surgical incision. For post-operative pain control, a continuous epidural infusion was started using a two day infusor containing 6 mg of morphine in 100 ml of 0.125% bupivacaine (Group 1, n = 20) or 100 ml of 0.125% ropivacaine (Group 2, n = 20). Visual analog scale (VAS) for pain during rest and movement, sensory change and motor blockade were assessed for 48 hrs. after surgery.
There were no significant differences in VAS for pain during rest and movement. The incidences of side effect were similar in both groups.
Using 0.125% bupivacaine with morphine via the epidural route provided similar pain relief and side effects as 0.125% ropivacaine with morphine.
Key Words: Analgesia: pain; postoperative; Anesthetic techniques: epidural; Anesthetics, local: bupivacaine; ropivacaine
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