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Korean Journal of Anesthesiology 1999;37(1):25-30.
DOI: https://doi.org/10.4097/kjae.1999.37.1.25   
The Effects of Clonidine and Midazolam to Prevent Vomiting after Strabismus Surgery in Childeren.
Kyoung Ok Kim, Han Chul Kim, Hee Soo Kim, Chong Sung Kim
Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea.
Postoperative vomiting is a troublesome problem in pediatric patients undergoing strabismus surgery. We compared the effect of clonidine and midazolam to prevent vomiting in a randomized, single-blind, placebo-controlled study of 60 healthy children undergoing surgical correction of strabismus.
The children, aged 3~15 years, were randomly allocated into three groups. The children in group 1 received clonidine 4 microgram/kg per oral about 90 min before induction of anaesthesia. Those in group 2 received midazolam 75 microgram/kg intravenously after induction before surgery. Those in group 3 received a placebo. Anaesthesia consisted of enflurane, nitrous oxide in oxygen, vecuroniun and thiopental.
There was no difference among the groups with respect to age, gender, weight, duration of anaesthesia and recovery room time. The data showed that clonidine 4 microgram/kg per oral before induction of anaesthesia was significantly effective in preventing vomiting (P<0.017). But there was no significant difference between the midazolam group and the placebo group.
We recommend the prophylactic administration of clonidine 4 microgram/kg per oral to children 3~15 years old because it decreases postoperative vomiting. It also provides preoperative sedation, postoperative analagesia, perioperative hemodynamic stability and a reduction in the volatile anesthetic requirement.
Key Words: Surgery, strabismus; Complication, postanesthetic, vomiting; Premedication, clonidine, midazolam


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