| Epidural Nalbuphine Reduces the Side Effects from Epidural Morphine after Cesarean Section. |
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Jeong Chan Ahn, Sang Keun Lee, In Suk Han, Sa Chung Jang |
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Department of Anesthesiology, Il Sin Christian Hospital, Pusan, Korea. |
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| Abstract |
BACKGROUND
This study was undertaken to reduce the side effects of epidural morphine through the addition of nalbuphine in 37 cesarean delivery.
METHODS
Forty patients were divided into 2 groups; M(control) group: bolus administration of morphine 2 mg in 0.5% bupivacaine and continuous epidural 41 hour-infusion of morphine 7mg, N(experimental) group: bolus administration of morphine 2 mg in 0.5% bupivacaine combined with nalbuphine 10mg and continuous epidural 41 hour-infusion of morphine 7mg combined with nalbuphine 10mg via the Paragon infusor.
RESULTS
During the postoperative 48 hours, their pain scores and side effects were recorded at 6, 12, 18, 24, 30, 36, 42 and 48 hours. The analgesic effects were good in two groups(mean VAS <3.0) and pain scores were statistically significant at 18 and 30 hour. The incidence of pruritus, nausea, vomiting and urinary retention was decreased in group N(p<0.05).
CONCLUSIONS
We concluded that continuous epidural morphine combined with nalbuphine was one of recommendable methods to reduce side effects of morphine. |
| Key Words:
Analgesia postoperative; Analgesics morphine; nalbuphine; Anesthetic techniques epidural |
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