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Korean Journal of Anesthesiology 1992;25(6):1206-1211.
DOI: https://doi.org/10.4097/kjae.1992.25.6.1206   
Effect of Clonidine Premedication on Isoflurane Induced Hypotensive Anesthesia.
Sung Min Han
Department of Anesthesiology, College of Medicine, University of Ulsan, Korea.
Abstract
The effect of single dose clonidine premedication on the vapour requirement for isoflurane induced hypotension in 20 patients undergoing spine surgery was evaluated. The patients given 5 ug/kg of clonidine P.O. at 90 minutes before operation required a mean expired isoflurane concentration of 1.2+/-0.5 vol% to induce hypotension compared with 2.1+/-0.6 vol% in 0.2 mg/kg of diazepam predmedication group(P<0.05). To achieve satisfactory hypotension, six out of ten patients in diazepam premedication group and l out of 10 patients in clondine premedication group are required supplementary infusion of sodium nitroprusside. In conclusion, clonidine premedication is recommended in isoflurane induced hypotensive anesthesia.
Key Words: Premedication; Clonidine; Induced hypotension; Isoflurane


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