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Korean Journal of Anesthesiology 1993;26(2):303-309.
DOI: https://doi.org/10.4097/kjae.1993.26.2.303   
A Comparative Study of the Prolongation of Epidural Anesthesia with 0.5 % Bupivacaine by Epinephrine and Clonidine.
Mi Kyung Lee, Suk Min Yoon, Il Ok Lee, Sang Ho Lim, Nan Suk Kim, Young Suk Choi
Department of Anesthesiology, Korea University, College of Medicine, Seoul, Korea.
Epidural clonidine is reported to produce analgesia in humans. To investigate the analgesic effect and prolongation of epidural and spinal anesthesia, we mixed 0.2mg epinephrine, 150 mcg clonidine, or 1 cc normal saline with 0.5% bupivacaine and compared the hemodynamie and analgesic effects of each drug. Heart rate and blood pressure were checked before, during and after anesthesia. Sensory level was checked by pin-prick method. The results were as follows; 1) The analgesia onset time and the time to highest level of sensory loss was most rapid in the epinephrine group. 2) The two segment regression time was significantly prolonged in the epinephrine group. 3) The analgesia duration was significantly prolonged in the clonidine and epinephrine group. 4) Although the heart rate gradually decreased over 60 min. After injection of each drug, there was no significant change between the groups. 5) Blood pressure decreased over 20-30 min. After injection of each drug, but there was no significant change between the groups.
Key Words: Epidural anesthesia; Prolongation; Epinephrine; Clonidine


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