| Cardiovascular Effects of Acute Isovolemic Hemodilution. |
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Kook Hyun Lee, Young Jin Lim, Kwang Won Yum |
1Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea.
2Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University, Seoul, Korea. |
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| Abstract |
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Acute normovolemic hemodilution is widely used to conserve blood and to minimize the need for homologous blood transfusion during operation. To evaluate the effects of aeute isovolemic hemodilution on hemodynamics and oxygen transport, pulmonary artery catheter and radial artery catheter were introduced in 8 patients in whom maxillofacial or Wertheim's operation were performed. Blood(estimated from allowable blood loss) was withdrawn from radial artery, and simultaneously replaced by intravenous administration of 5% plasmanate and Hartmann solution. Acute isovolemic hemodilution decreased the hematocrit level from 33.2+/-3.7% to 29.6+/-2.9%. Cardiac output increased significantly, which was associated with decreased systemic vaacular resistance. Oxygen transport and oxygen consumption increased despite a decrease in oxygen carrying capacity.
Heart rate, mean arterial perssure, mean pulmonary arterial pressure, central venous pressure, and pulmonary capillary wedge pressure did not change significantly during hemodilution. The results indicate that blood perfusion and oxygenation to tissue were well maintained in the hemodilution of the magnitude used in this study. Therfore it could be concluded that acute isovolemic hemodilution is a safe and relatively simple method of conserving blood and minimizing homologous blood transfusion. |
| Key Words:
Acute isovolemic hemodilution; Cardiac output; Oxygen transport |
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