An Experimental Study of the Effects of Low Molecular Weight Dextran ( Rheomacrodex ) on Blood Oxygen Content .

Kim,  Kwang Min; Yum,  Kwang Won; Kim,  Yong Lack; Kim,  Kwang Woo; Kwak,  II Yong

doi:1976.9.2.263

Experimental Research Article

Korean Journal of Anesthesiology 1976;9(2):263-270.
DOI: https://doi.org/10.4097/kjae.1976.9.2.263

An Experimental Study of the Effects of Low Molecular Weight Dextran ( Rheomacrodex ) on Blood Oxygen Content .

Kwang Min Kim, Kwang Won Yum, Yong Lack Kim, Kwang Woo Kim, II Yong Kwak

¹Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea.
²Department of Anesthesiology, Capital Military Hospital, ROK Army, Korea.

Abstract

Arterio-venous oxygen content difference (Ca-vDO2) were measured with IL 213 Blood Gas Analyzer and blood oxygen utilization ratio (percentile of Ca-vDO2 versus arterial oxygen content in 100ml of blood) were calculated in 21 dogs bled until the mean arterial pressure fell to 80~100mmHg. Comparison of blood oxygen utilization ratios among autotransfused dogs, Hartmanns solution-infused dogs, and Rheomacrodex-infused dogs after bleeding through the femoral vein into the ACD bottle revealed that the blood oxygen utilization ratio in the Rheomacrodexinfused dogs was significantly decreased, which might be related to increased cardiac output due to its higher osmolality and blood viscosity-decreasing effect.