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Korean J Anesthesiol > Volume 25(3); 1992 > Article
Korean Journal of Anesthesiology 1992;25(3):493-502.
DOI: https://doi.org/10.4097/kjae.1992.25.3.493   
An Experimental Study on the Effects of Halothane Anesthesia on the Hepatic Function of Rats Pretreated with Ethyl Alcohol.
Won Young Chang, Kun Chun Choi, Hye Won Lee, Seong Ho Chang, Jung Soon Shin
1Department of Anesthesiology, College of Medicine, Korea University, Seoul, Korea.
2Department of Anesthesiology, Seoul Adventist Hospital, Seoul, Korea.
The effects of halothane anesthesia on the liver function were investigated in 78 male Sprague-Dawley rats pretreated with ethyl alcohol. Blood sampling was done before intravenous administration of ethyl alcohol(400 mg/kg, 5 ml/kg, 9.99 vol %) or saline(5 ml/kg)through tail vein of the rat. Twentyfour hours later, all rats were randomly assigned to receive one of two anesthetic managements for two hours; 1) halothane -N2O-O2 2)N2O-O2 Bood sample and hepatic tissue were obtained 24 or 96 hours after anestheia Measurements of hepatic function(protein, albumin, cholesterol, bilirubin, blood urea nitro- gen, creatinine) were made and hepatic tissue was examined with light microscopy. The results are as follows; 1) There was no siginificant difference in the laboratory findings between the alcohol and saline groups. 2) There was no significant difference in the laboratory findings between the halothane and nitrous oxide anesthesia. 3) No difference in histologic injury was found between alcohol and saline groups. 4) No difference in histologic injury was found between halothane-nitrous oxide-oxygen and nitrous oxide-oxygen ansthesia groups.
Key Words: Halothane; Ethyl alcohol; Hepatotoxicity
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