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Korean J Anesthesiol > Volume 25(4); 1992 > Article
Korean Journal of Anesthesiology 1992;25(4):648-655.
DOI: https://doi.org/10.4097/kjae.1992.25.4.648   
Evaluation of Anesthetic Effects of Enflurane by Spectrum Analysis of Rat EEG.
Mann Gee Lee, Woon Yi Baek, Byung Kwon Kim, Choong Young Kim
1Department of Pharmacology, School of Medicine, Kyungpook National University, Taegu, Korea.
2Department of Anesthesiology, School of Medicine, Kyungpook National University, Taegu, Korea.
To evaluate the depth of enflurane anesthesia, spectrum analysis of rat EEG was used. Bipolar EEG was recorded through one lead form rat scalp during inhalation with 1,2,3 and 4% of enflurane, and analysed to produce the spectrum from which the density of each band(delta 1-3.25Hz, theta 3.5-7.75Hz, alpha 8-12.75Hz, beta2 18-20.75Hz, and beta3 21-31.75Hz)and total density, and medican power frequency were calculated. Differences among the EEG patterns, which were represented by F values through discriminant analysis of those 8 variables, in each level of anesthesia were significant among all concentrations except between 1% and 2% enflurane administration. The results suggest that the discriminat anlysis for the EEG parameters derived from power spectrum analysis can apply to determine the level of enflurane anesthesia.
Key Words: Enflurane; EEG; Spectrum analysis; Rat
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