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Korean J Anesthesiol > Volume 40(3); 2001 > Article
Korean Journal of Anesthesiology 2001;40(3):420-426.
DOI: https://doi.org/10.4097/kjae.2001.40.3.420   
The Evaluation of Topical Anesthetic Effects of a Liposome Encapsulated Mixture of Local Anesthetics (Lipo-MLA).
Sung Sik Park, Kyu Seok Han, Woon Yi Baek
Department of Medicine, Graduate School, Kyungpook National University, Daegu, Korea.
Abstract
BACKGROUND
This study investigated the effect of topical analgesic effects of a liposome encapsulated mixture of local anesthetics (lipo-MLA) compared with EMLA.
METHODS
3% lipo-MLA (0.5% tetracaine base, 2.5% lidocaine base) and 5% lipo-MLA (1% tetracaine base, 4% lidocaine base) were encapsulated into liposomal vesicles made with egg yolk phosphatidylcholine, cholesterol and phosphatidyldioleoyl. 3% lipo-MLA and EMLA were applied to volunteers' forearms bilaterally with and without an occlusive dressing. The topical anesthetic effects of the lipo-MLA and EMLA as a control were evaluated by the pinprick test in 28 adult volunteers after 60 minutes of application. The analgesic influence of the concentration of local anesthetics was also compared with 3% and 5% lipo-MLA under a non-occlusive dressing.
RESULTS
Analgesic effects of the 3% lipo-MLA were similar with EMLA under an occlusive dressing for 60 minutes. In addition, analgesic effects of the 3% lipo-MLA under a non-occlusive dressing were more potent than EMLA. Lipo-MLA under a non-occlusive dressing showed more potent analgesic effect than lipo-MLA under an occlusive dressing. 5% lipo-MLA was more potent than 3% lipo-MLA under a non-occlusive dressing.
CONCLUSIONS
Lipo-MLA has more potent analgesic effects than EMLA without an occlusive dressing and 5% lipo-MLA is more potent than 3% lipo-MLA. Therefore, lipo-MLA appeared to be an improved topical analgesic formulation which provides a more potent and convenient topical application.
Key Words: Anesthetics, local: lidocaine; liposome; tetracaine
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