| Effect of Succinylcholine on Gastric Smooth Muscle Contraction in Rabbits. |
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Won Hyung Lee, Ik Soo Kim |
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Department of Anesthesiology, Chungnam National University, Medical College, Daejeon, Korea. |
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| Abstract |
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Succinylcholine(5mg/kg) without pretreatment or succinylcholine(5mg/kg) with pretreatment using atropine 2mg/kg, pancuronium at 0.1 mg/kg, at 0.3 mg/kg, and 1 mg/kg were given to rabbits of the same genus(body weight 1.6~2.3kg) under subsutaneous urethane anesthesia to determine the effect on gastric pressure in each group. The results are summerized as follows 1) Gastric pressure was significantly increase by the administration of succinylcholine(5mg/kg).(p<0.05) 2) The increase in gastric pressure was significantly depressed by pretreatment with 2mg of atropine at the five minute mark, but gradually recovered in time. 3) The trend of depression of gastric pressure increase was noticed by pretreatment with pancuronium 0.1mg/kg, but with 0.3mg/kg, 1mg/kg of pancuronium, the suppression was significantly apparent. |
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