Korean J Anesthesiol Search

CLOSE


Korean J Anesthesiol > Volume 52(1); 2007 > Article
Korean Journal of Anesthesiology 2007;52(1):77-80.
DOI: https://doi.org/10.4097/kjae.2007.52.1.77   
The Effects of Ketamine on Rat Myometrial Contractility.
Tae Hun An, Keum Young So
Department of Anesthesiology and Pain Medicine, Chosun University College of Medicine, Gwangju, Korea. than@chosun.ac.kr
Abstract
BACKGROUND
It has been reported that ketamine induced contraction of the uterus. Therefore, it has been recommended as a suitable obstetric anesthetic agent. However, some investigators reported that ketamine inhibited contraction of rat uterine smooth muscle. There has been argument about its effect on the uterine contraction. The aim of the present study was to investigate the effect of ketamine on rat uterine contractile activity in vitro.
METHODS
Uterine smooth muscle tissues were obtained from non-pregnant rats (n = 20). The uterine ring segments were mounted in organ bath filled with Krebs solution with 95% O2 and 5% CO2. After spontaneous activity had been accomplished, ketamine in various concentrations (10(-7) M to 10(-3) M) was added cumulatively to the bath and the effects were continuously registered.
RESULTS
Ketamine in dose of 10(-5) M increased spontaneous myometrial contractile activity. But, ketamine in doses of 10(-4) to 10(-3) M induced a dose-dependent inhibition of spontaneous myometrial contractile activity.
CONCLUSIONS
Ketamine constricted the uterine smooth muscle in concentration of 10(-5) M but, relaxed the uterine smooth muscle in high concentrations (10(-4) to 10(-3) M).
Key Words: ketamine; rat; uterine contractility


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-795-5129    Fax: +82-2-792-4089    E-mail: anesthesia@kams.or.kr                

Copyright © 2019 by Korean Society of Anesthesiologists. All rights reserved.

Developed in M2community

Close layer
prev next