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Korean Journal of Anesthesiology 1989;22(3):424-430.
DOI: https://doi.org/10.4097/kjae.1989.22.3.424   
The Effects of Fentanyl and Bupivacaine Mixture in Epidural Anesthesia for Cesarean Section .
Hyeong Gu Lee, Mi Hee Kim, Jun Rae Lee, Young Jin Han
Department of Anesthesiology, Chonbuk National University Medical School, Chonju, Korea.
This study was performed to investigate the effects of fentanyl in epidural bupivacaine anesthesia for Cesarean section. 45 patients were enrolled in this study. The patients in group I(N=15) received 0.9% NaC1 2ml mixed with 20ml of bupivacaine 0.5%, group II(N=15) received 0.9% NaC1 1ml and fentanyl 50 ug mixed with 20 ml of bupivacaine 0.5%, and group IlI(N =15) received fentanyl 100ug mixed with 20 ml of bupivacaine 0.5%. The time of onset, segmental spread of analgesia, duration of analgesia, changes in arterial blood pressure and heart rate, the incidence of side effects, Apgar score and early neonatal neurobehavioral scale were observed after epidural anesthesia. The results were as follows 1) The time of onset and segmental spread of analgesia were very significantly shorter in group III compared to group I and group lI. 2) The spread of sensory blockade at 30 minutes after epidural injection showed no significant differences among the three groups. 3) The mean duration of analgesia was significantly longer in group IlI compared to group I and II. 4) There were no significant differences in the occurence of side effects among the three groups. 5) There were no significant differences in the Apgar score and early neonatal neurobehavioral scale among the neonates of the three groups. The above results suggested that fentanyl 100ug can be used as a good adjuvant for epidural anesthesia with bupivacaine for Cesarean section.
Key Words: C-section; Epidural anesthesia; Fentanyl and bupivacaine mixture
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