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Korean J Anesthesiol > Volume 76(2); 2023 > Article
Shin, Kim, Han, Do, and Na: Ultrasound assessment of residual gastric volume in older adults undergoing staged-bilateral total knee arthroplasty after consuming carbohydrate-containing fluids: a prospective observational study



We compared preoperative residual gastric volume (GV) between the first and second stages of total knee arthroplasty (TKA) in older adults after drinking carbohydrate-containing fluid 2 h prior to surgery.


In this study, 36 patients, aged > 65 years, scheduled for staged bilateral TKA with one-week interval, were enrolled. The patients consumed 400 ml of carbohydrate-containing fluid 2 h prior to surgery. Before the induction of spinal anesthesia, the gastric antral cross-sectional area was measured at the first and second TKA using ultrasound, and the residual GV was calculated. The primary outcome was the residual GV. Qualitative GV (grades 0, 1, and 2) and analgesic consumption after the first TKA were assessed as secondary outcomes.


The GV (median [Q1, Q3]) was greater in the second-stage TKA (41.1 [22.5, 62.8] ml) than in the first-stage TKA (10.3 [0.0, 27.1] ml) (P < 0.001). In the qualitative assessment, the distribution was not different between the two stages of TKA (P = 0.219) and only one patient showed grade 2 gastric content in the second TKA. When opioid consumption was converted to an equivalent dose of morphine, an average of 53.9 mg of morphine was required after the first TKA.


Residual GV after drinking carbohydrate-containing fluid differed according to the stage of TKA, showing a larger residual GV in the second TKA than in the first one. In older adults scheduled to undergo bilateral staged TKA, caution is required in preoperative fasting practice, especially in second-stage surgery.


Although modern preoperative fasting guidelines encourage the consumption of carbohydrate-containing fluid 2 h prior to surgery [1], it is debatable whether this practice is appropriate and safe in all patients undergoing various types of surgery [2,3]. One study demonstrated that fasting time was not associated with residual gastric volume (GV), showing that the incidence of full stomach was 35% in patients who had unplanned surgery and fasted for at least 6 h [4]. Even in scheduled laparoscopic cholecystectomy, 13% of patients showed a full stomach despite adherence to the recommended fasting time [5].
In our institution, many patients undergo staged bilateral total knee arthroplasty (TKA) at weekly intervals, most of whom are older adults with degenerative arthritis. As recommended, older adult patients who underwent TKA drank carbohydrate-containing fluid 2 h prior to surgery. In staged bilateral TKA, additional points should be considered when applying fasting guidelines. In addition to advanced age [6] that can affect gastric emptying time, the patient’s physical, medical, and psychological conditions may differ during the first and second operations [7]. For example, the effect of the acute pain after the first TKA and subsequent opioids use on gastric motility cannot be ignored [7,8]. However, to date, no studies have examined the residual GV of older adult patients with staged bilateral TKA and whether there is a difference according to the stage when carbohydrate-containing fluid is ingested.
Our hypothesis is that the preoperative residual GV of older adults drinking carbohydrate-containing fluid 2 h before surgery may be different between the first and second TKA. This study evaluated and compared preoperative residual GV measured using ultrasonography in older adults undergoing staged bilateral TKA.  

Materials and Methods

This prospective observational study was conducted at Seoul National University Bundang Hospital between March 2021 and March 2022 according to institutional and Good Clinical Practice guidelines. This study complied with the 2013 Declaration of Helsinki. The study protocol was registered at ClinicalTrials.gov (NCT04814706, registered on March 24, 2021) after obtaining approval of the Institutional Review Board on March 16, 2021 (B-2103/673-302; Chairperson, Hak Chul Jang; Seoul National University Bundang Hospital).
The subjects were older adults (65 – 85 years) scheduled for staged bilateral TKA with one-week interval under spinal anesthesia. Patients with chronic kidney disease, diabetes mellitus, previous history of esophagus or stomach surgery, gastroesophageal reflux disease, and an American Society of Anesthesiologists physical status score > 3 were excluded. All patients provided written informed consent before participation.
The enrolled patients consumed 400 ml carbohydrate-containing fluid (Nucare NoNPO®; 12.8% maltodextrin, 50 kcal/100 ml, 0.52 mg/ml sodium, 0.48 mg/ml potassium; Daesang Wellife, Korea) 2 h prior to surgery. In addition, 75 mg of pregabalin, 200 mg of celecoxib, and 650 mg of acetaminophen were administered with sips of < 20 ml of water 1 h prior to surgery for pre-emptive analgesia.
Residual GVs were measured twice before the first and the second TKA by ultrasound. Ultrasound examination was performed in the preoperative holding area in a semi-recumbent and right-lateral decubitus (RLD) position for the greatest sensitivity [9]. A cross-sectional image of the gastric antrum was identified using a low-frequency convex array transducer (probe rC60xi, 2 – 5 MHz) equipped with an ultrasound machine (SonoSite EDGE II, Fusifilm SonoSite Inc., USA). The gastric antrum was evaluated according to a standard protocol [10].
Both quantitative and qualitative methods were used to assess the residual GV. Images of the gastric antrum taken between peristaltic contractions were used to calculate the cross-sectional area (CSA). The CSA of the antrum in the RLD was calculated using two perpendicular anteroposterior (AP) and craniocaudal (CC) diameters of the antrum (Fig. 1): CSA = π × AP × CC / 4.
CSA was measured three times and the average value of the three measurements was applied to the following formula to calculate the residual GV that was validated previously [11]: GV (ml) = 27.0 + 14.6 × RLD-CSA (cm2) – 1.28 × age (year). In the formula, RLD-CSA refers to the antral CSA measured in the RLD position. A calculated GV of less than zero was considered 0 ml.
Qualitative assessment was performed using a simple three-point grading system as defined by Perlas et al. [12]. Grade 0, completely empty antrum in both semi-recumbent and RLD positions; grade 1, empty antrum in the semi-recumbent position but visible fluid in the RLD position; grade 2, visible fluid in the antrum in both positions, implying a high-volume state.
Tramadol and morphine were administered for postoperative pain control. When the patient complained of a numeric rating scale score ≥ 4, 100 mg of tramadol was administered. Tramadol was administered up to four times a day, at least 4 h apart. When pain control was insufficient, as per the basic protocol described above, additional 5 mg of morphine was administered.
The primary outcome was the calculated GV. Qualitative assessment of GV (grades 0, 1, and 2) and analgesic consumption after the first TKA were included in the secondary outcomes.


Sample size calculation was performed using G*Power software (ver. 3.1; Heinrich-Heine-Universität Düsseldorf, Germany). In our pilot study, the residual GV was 39.4 ± 39.1 ml prior to the first TKA. Considering that the 50% increase in the second TKA was statistically significant, 35 participants were required for an alpha level of 0.05 and a power of 80%. Assuming an overall loss to follow-up rate of 10%, a total of 39 participants were needed in the present study.
After a normality check using the Shapiro-Wilk test, paired t-test for CSA in a semi-recumbent position and Wilcoxon signed rank test for RLD-CSA and GV were used. For the comparison of qualitative assessment of GV (categorical data) between the two stages, the McNemar-Bowker test was used. Continuous variables are presented as mean ± standard deviation (SD) or median with interquartile range, and categorical variables are presented as numbers (proportions). Statistical Package for Social Sciences (SPSS; ver. 25; IBM Corp., USA) and Stata SE version 17 (Stata Corp., USA) software was used for the calculations, and all P values < 0.05 were considered significant. 


A total of 39 patients who were scheduled for staged bilateral TKA were enrolled in this study. Among them, three patients were excluded because of poor ultrasound images (Fig. 2). Patient characteristics are shown in Table 1.

Ultrasound evaluation of residual GV

The CSA measured in either the semi-recumbent or RLD position differed significantly between the first and second TKA (Table 2). Accordingly, the preoperative GV (median [Q1, Q3]) was significantly different between the first and second TKA (10.3 [0.0, 27.1] ml vs. 41.1 [22.5, 62.8] ml) (P < 0.001), and the mean difference in GV was 35.0 ml (95% CI [21.6, 48.5] ml). At the second TKA, a GV > 1.5 ml/kg, a criterion considered high risk for pulmonary aspiration [13,14] was observed in six patients. However, no patient presented pulmonary aspiration.
In the qualitative assessment, the distribution was not different between the two stages of TKA (P = 0.219) and only one patient showed grade 2 gastric content in the second TKA, whose calculated residual GV was 109.1 ml (1.6 ml/kg).

Opioid consumption

The amount of opioid consumption after the first TKA was also investigated (Table 3). Among the 36 patients, five did not require rescue analgesics for postoperative pain control. The mean doses (mean ± SD) of tramadol and morphine were 522.2 ± 434.9 mg and 1.7 ± 4.6 mg, respectively. When tramadol was converted to an equivalent dose of morphine, an average of 53.9 mg of morphine was required after the first TKA.  


This study found that the preoperative residual GV in the second TKA was greater than that in the first TKA when gastric ultrasonography was performed in older patients after consuming carbohydrate-containing fluid 2 h prior to each surgery. Previous studies have shown that preoperative carbohydrate intake in older patients does not change the gastric emptying time, residual GV, or gastric contents [2,15,16]. However, repeated surgeries that were performed at one-week interval increased the preoperative residual GV under the same fasting condition.
One notable aspect of this study was that residual GV > 1.5 ml/kg was observed in six patients before the second TKA operation that fortunately did not manifest as pulmonary aspiration. Although the strict threshold of GV that increases the risk of pulmonary aspiration is controversial, recent reports have announced that patients with GV > 1.5 ml/kg are a high-risk group for pulmonary aspiration [13,14], and residual GV > 1.5 ml/kg was occasionally observed in fasted patients suggesting incomplete gastric emptying [5,17]. However, there was a report that no one had a residual GV > 1.5 ml/kg after 2 h of drinking carbohydrate-containing fluid in ambulatory surgery [18], and in our study, there was no patient with a residual GV > 1.5 ml/kg in the first TKA. Further studies are needed to determine whether the same criteria should apply to patients taking carbohydrate-containing fluid before surgery and whether a residual GV > 1.5 ml/kg is appropriate to defer elective surgery for the prevention of pulmonary aspiration.
Various factors such as diabetes mellitus, chronic kidney disease, Parkinson’s disease, advanced age, and drug-induced gastroparesis have been known to be associated with delayed gastric emptying [19]. Among them, the effect of stress, especially emotional stress, on gastric motility is an ongoing debate and few studies have investigated the effect of surgery-induced stress on gastric emptying [20]. In the present study, since TKA was performed twice in one patient with one-week interval, stress caused by the first TKA was expected to affect gastric motility before the second TKA [21]. Unfortunately, the severity of patients’ stress was not measured using objective tools. Several tools, such as the Hospital Anxiety and Depression Scale [22], a brief measure of emotional preoperative stress [23], State-Trait Anxiety Inventory Form X [24], or a 10-items perceived stress scale [25], can be evaluated in future study. In addition, the levels of several stress biomarkers such as cortisol, interleukin-6, tumor necrosis factor-α, and C-reactive protein can be evaluated and compared.
Postoperative acute pain can be considered as one of the contributing factors for increased GV in the second TKA. Pain, a significant stressor [26], activates sympathetic reflex [27] and participates in the release of stress-related neuropeptides [28]. The sympathetic nervous system and neuropeptides have an inhibitory role over gastrointestinal muscle tone and motility, resulting in delayed gastric emptying [29]. Acute surgical pain added to chronic pain of the knee could influence the gastric emptying time, which might result in an increased residual GV before the second surgery [7,8].
Finally, the role of opioids used for postoperative analgesia should be considered. It is well known that opioid receptors are widely distributed in the body and play a critical role in various physiological processes, including immunological response, growth, and pain modulation [30]. In addition to these physiological processes, opioids play an inhibitory role in tonic/segmental contraction, peristalsis, and secretion in the gastrointestinal tract by binding to peripheral μ-opioid receptors, and consequently, intestinal propulsion is impaired and bowel transit time is delayed [30]. In the present study, most patients requested additional rescue analgesics during the rehabilitation period after the first TKA, and the mean dose of morphine equivalent was 54 mg. Since gastric emptying is suppressed even with a small dose of morphine [31], opioid analgesics administered after the first TKA may have contributed to the increase in residual GV before the second TKA. Unfortunately, however, our results did not show any correlation between residual GV changes and the amounts of opioid administered (R2 = 0.043, P = 0.804). Still interestingly, although there was no statistical difference, six patients with residual GV > 1.5 ml/kg showed more morphine equivalent dose (MED) than the others did (67.0 ± 46.5 mg vs. 51.3 ± 42.3 mg, P = 0.186).
Taken overall, this study could not identify a clear mechanism for why the residual GV was larger in the second TKA than in the first one. A larger well-planned trial is required to evaluate the correlation between the residual GV and opioid use or the severity of stress. Another limitation is that our results cannot be generalized to all populations, since the enrolled cohort consisted of older adults. TKA is a surgery mainly performed on elderly patients, so there would be no study conducted on younger patients in the same operation. It is necessary to perform a study on younger patients under similar surgical conditions. Last, the volume effect of water consumed for pre-emptive oral analgesic medication on the residual GV cannot be ignored. However, the allowed volume of water for oral medication was less than 20 ml. Furthermore, in some studies, the mean residual GV was approximately 37 – 83 ml even after 8 h of fasting before surgery [18,19]. Therefore, even if a small amount of water for oral analgesic medication is added to the residual GV identified as a result of this study, most of the cases do not seem to reach the GV amount observed in fasted people.
In conclusion, the residual GV differed according to the stage of TKA, with a larger residual GV in the second surgery than in the first. Hence, in older adults scheduled for bilateral staged TKA, caution is required when ingesting 400 ml carbohydrate-containing fluid 2 h before surgery, especially in the second surgery.




Conflicts of Interest

No potential conflict of interest relevant to this article was reported.

Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Author Contributions

Hyun-Jung Shin (Conceptualization; Data curation; Formal analysis; Investigation; Methodology; Validation; Writing – original draft; Writing – review & editing)

Heeyeon Kim (Investigation; Methodology)

Sung-Hee Han (Conceptualization; Investigation; Methodology)

Sang-Hwan Do (Conceptualization; Methodology)

Hyo-Seok Na (Conceptualization; Data curation; Supervision; Writing – review & editing)

Fig. 1.
Ultrasound image of the gastric antrum in the epigastric area obtained in a sagittal or parasagittal plane. AP: antero-posterior diameter of antrum, CC: cranio-caudal diameter of antrum, P: pancreas.
Fig. 2.
Patient inclusion flow chart.
Table 1.
The Characteristics of Patients
Variable n = 36
Age (yr) 71.0 ± 4.4
Weight (kg) 63.5 ± 8.4
Height (cm) 152.3 ± 5.4
BMI (kg/m2) 27.3 ± 2.8
ASA-PS (I/II/III) 3/30/3
Anesthesia time (min)
 1st / 2nd 127.1 ± 17.3/121.4 ± 19.8
Operation time (min)
 1st / 2nd 88.3 ± 10.2/84.4 ± 13.8

Values are presented as mean ± SD or number of patients. BMI: body mass index, ASA-PS: American Society of Anesthesiologists physical status.

Table 2.
Comparison of Residual GV
First TKA (n = 36) Second TKA (n = 36) P value
Quantitative analysis
 CSA (semi-recumbent, cm2) 3.0 ± 1.0 3.9 ± 1.6 0.001
 CSA (RLD, cm2) 5.3 (4.0, 6.3) 7.1 (5.9, 8.5) < 0.001
 GV (ml) 10.3 (0.0, 27.1) 41.1 (22.5, 62.8) < 0.001
 GV (ml/kg) 0.2 (0.0, 0.4) 0.6 (0.3, 1.0) < 0.001
Qualitative assessment 0.219
 Grade 0 21 (58) 17 (47)
 Grade 1 15 (42) 18 (50)
 Grade 2 0 (0) 1 (3)

Values are presented as mean ± SD, median (Q1, Q3), or number of the patients (%). TKA: total knee arthroplasty, CSA: cross-sectional area, RLD: right-lateral decubitus, GV: gastric volume. GVs were presented in calculated total volume and in unit volume per body weight, respectively. Paired t-test for CSA in a semi-recumbent position. Wilcoxon signed rank test for CSA in RLD and GV. McNemar-Bowker test for the comparison of qualitative assessment of GV.

Table 3.
Opioid Consumption after the First TKA
n = 36
Tramadol (mg) 522.2 ± 434.9
MED of tramadol (mg) 52.2 ± 43.5
Morphine (mg) 1.7 ± 4.6
Total MED (mg) 53.9 ± 42.8

Values are presented as mean ± SD. TKA: total knee arthroplasty, MED: morphine equivalent dose.


1. Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures: an updated report by the American Society of Anesthesiologists task force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration. Anesthesiology 2017; 126: 376-93.
crossref pmid
2. Hellstrom PM, Samuelsson B, Al-Ani AN, Hedstrom M. Normal gastric emptying time of a carbohydrate-rich drink in elderly patients with acute hip fracture: a pilot study. BMC Anesthesiol 2017; 17: 23.
crossref pmid pmc pdf
3. Leviter J, Steele DW, Constantine E, Linakis JG, Amanullah S. “Full stomach” despite the wait: point-of-care gastric ultrasound at the time of procedural sedation in the pediatric emergency department. Acad Emerg Med 2019; 26: 752-60.
crossref pmid pdf
4. Dupont G, Gavory J, Lambert P, Tsekouras N, Barbe N, Presles E, et al. Ultrasonographic gastric volume before unplanned surgery. Anaesthesia 2017; 72: 1112-6.
crossref pmid pdf
5. Chang JE, Kim H, Won D, Lee JM, Jung JY, Min SW, et al. Ultrasound assessment of gastric content in fasted patients before elective laparoscopic cholecystectomy: a prospective observational single-cohort study. Can J Anaesth 2020; 67: 810-6.
crossref pmid pdf
6. Moore JG, Tweedy C, Christian PE, Datz FL. Effect of age on gastric emptying of liquid--solid meals in man. Dig Dis Sci 1983; 28: 340-4.
crossref pmid pdf
7. Leslie JB, Viscusi ER, Pergolizzi JV Jr, Panchal SJ. Anesthetic routines: the anesthesiologist’s role in GI recovery and postoperative ileus. Adv Prev Med 2011; 2011: 976904.
crossref pmid pmc pdf
8. Dahl JB, Mathiesen O, Kehlet H. An expert opinion on postoperative pain management, with special reference to new developments. Expert Opin Pharmacother 2010; 11: 2459-70.
crossref pmid
9. Bouvet L, Barnoud S, Desgranges FP, Chassard D. Effect of body position on qualitative and quantitative ultrasound assessment of gastric fluid contents. Anaesthesia 2019; 74: 862-7.
crossref pmid pdf
10. Cubillos J, Tse C, Chan VW, Perlas A. Bedside ultrasound assessment of gastric content: an observational study. Can J Anaesth 2012; 59: 416-23.
crossref pmid pdf
11. Perlas A, Mitsakakis N, Liu L, Cino M, Haldipur N, Davis L, et al. Validation of a mathematical model for ultrasound assessment of gastric volume by gastroscopic examination. Anesth Analg 2013; 116: 357-63.
crossref pmid
12. Perlas A, Davis L, Khan M, Mitsakakis N, Chan VW. Gastric sonography in the fasted surgical patient: a prospective descriptive study. Anesth Analg 2011; 113: 93-7.
crossref pmid
13. Van de Putte P, Perlas A. Ultrasound assessment of gastric content and volume. Br J Anaesth 2014; 113: 12-22.
crossref pmid
14. Perlas A, Van de Putte P, Van Houwe P, Chan VW. I-AIM framework for point-of-care gastric ultrasound. Br J Anaesth 2016; 116: 7-11.
crossref pmid
15. Shin HJ, Koo BW, Lim D, Na HS. Ultrasound assessment of gastric volume in older adults after drinking carbohydrate-containing fluids: a prospective, nonrandomized, and noninferiority comparative study. Can J Anaesth 2022; 69: 1160-6.
crossref pmid pdf
16. Jeong JY, Ahn JH, Shim JG, Lee SH, Ryu KH, Lee SH, et al. Gastric emptying of preoperative carbohydrate in elderly assessed using gastric ultrasonography: a randomized controlled study. Medicine (Baltimore) 2021; 100: e27242.
crossref pmid pmc
17. Ohashi Y, Walker JC, Zhang F, Prindiville FE, Hanrahan JP, Mendelson R, et al. Preoperative gastric residual volumes in fasted patients measured by bedside ultrasound: a prospective observational study. Anaesth Intensive Care 2018; 46: 608-13.
crossref pmid pdf
18. Zhang Z, Wang RK, Duan B, Cheng ZG, Wang E, Guo QL, et al. Effects of a preoperative carbohydrate-rich drink before ambulatory surgery: a randomized controlled, double-blinded study. Med Sci Monit 2020; 26: e922837.
crossref pmid pmc
19. Camilleri M, Chedid V, Ford AC, Haruma K, Horowitz M, Jones KL, et al. Gastroparesis. Nat Rev Dis Primers 2018; 4: 41.
crossref pmid pdf
20. Woodhouse S, Hebbard G, Knowles SR. Psychological controversies in gastroparesis: a systematic review. World J Gastroenterol 2017; 23: 1298-309.
crossref pmid pmc
21. Desborough JP. The stress response to trauma and surgery. Br J Anaesth 2000; 85: 109-17.
crossref pmid
22. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67: 361-70.
crossref pmid
23. Wolmeister AS, Schiavo CL, Nazario KC, Castro SM, de Souza A, Caetani RP, et al. The brief measure of emotional preoperative stress (B-MEPS) as a new predictive tool for postoperative pain: a prospective observational cohort study. PLoS One 2020; 15: e0227441.
crossref pmid pmc
24. Kim YH, Choi WJ. Effect of preoperative anxiety on spectral entropy during induction with propofol. Korean J Anesthesiol 2013; 65: 108-13.
crossref pmid pmc
25. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav 1983; 24: 385-96.
crossref pmid
26. Haroutounian S. Postoperative opioids, endocrine changes, and immunosuppression. Pain Rep 2018; 3: e640.
crossref pmid pmc
27. Hohenschurz-Schmidt DJ, Calcagnini G, Dipasquale O, Jackson JB, Medina S, O’Daly O, et al. Linking pain sensation to the autonomic nervous system: the role of the anterior cingulate and periaqueductal gray resting-state networks. Front Neurosci 2020; 14: 147.
crossref pmid pmc
28. Kapritsou M, Papathanassoglou ED, Bozas E, Korkolis DP, Konstantinou EA, Kaklamanos I, et al. Comparative evaluation of pain, stress, neuropeptide Y, ACTH, and cortisol levels between a conventional postoperative care protocol and a fast-track recovery program in patients undergoing major abdominal surgery. Biol Res Nurs 2017; 19: 180-9.
crossref pmid pdf
29. Browning KN, Travagli RA. Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions. Compr Physiol 2014; 4: 1339-68.
crossref pmid pmc pdf
30. Sobczak M, Salaga M, Storr MA, Fichna J. Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives. J Gastroenterol 2014; 49: 24-45.
crossref pmid pdf
31. Yuan CS, Foss JF, O’Connor M, Roizen MF, Moss J. Effects of low-dose morphine on gastric emptying in healthy volunteers. J Clin Pharmacol 1998; 38: 1017-20.
crossref pmid


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