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Korean J Anesthesiol > Epub ahead of print
DOI: https://doi.org/10.4097/kja.22209    [Epub ahead of print]
Published online June 28, 2022.
Intrathecal dexmedetomidine attenuates mechanical allodynia through the downregulation of brain-derived neurotrophic factor in a mild traumatic brain injury rat
Soeun Jeon1, Jiseok Baik1,2, Jisu Kim1, Jiyoon Lee3, Wangseok Do1, Eunsoo Kim1,2, Hyeon Jeong Lee1,2, Hae-kyu Kim1,2
1Department of Anesthesia and Pain Medicine, Biomedical Research Institute, Pusan National University Hospital, Pusan, Korea
2School of Medicine, Pusan National University, Pusan, Korea
3Department of Anaesthesiology and Pain Medicine, Seoul National University, Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea
Corresponding author:  Jiseok Baik, Tel: +82 51 240 7399, Fax: +82 51 242 7466, 
Email: jidal75@naver.com
Received: 8 April 2022   • Revised: 20 June 2022   • Accepted: 23 June 2022
This study evaluated the effects of dexmedetomidine and propofol on the concentration of brain-derived neurotrophic factor in the cerebrospinal fluid (c-BDNF) and concomitant mechanical allodynia in a mild traumatic brain injury (TBI) rat.
After fixing the rat’s skull on a stereotactic frame under general anesthesia, craniotomy was performed. After impact, 10 µl of drug was injected into the cisterna magna (Group S: sham; Group D: dexmedetomidine 5 µg/kg; Group P: propofol 500 µg/kg; and Group T: untreated TBI). The 50% mechanical withdrawal threshold (50% MWT) and levels of c-BDNF were measured on postoperative days (PODs) 1, 7, and 14.
In group T, the 50% MWT measured on PODs 1, 7, and 14 were significantly lower, and the concentration of c-BDNF on POD 1 was significantly higher than that in group S. In group D, the c-BDNF levels on POD 1 were significantly lower than that in group T and was comparable with group S during the whole study period. The 50% MWT of group D was significantly higher than that of group T throughout the postoperative period. In group P, there were no significant differences in the 50% MWT and c-BDNF levels during the entire postoperative period when compared with those in group T.
Intrathecal administration of dexmedetomidine may attenuate TBI-induced mechanical allodynia for up to two weeks post-injury through the immediate suppression of c-BDNF in a mild TBI rat. The inhibition of c-BDNF expression in the acute phase reduced the occurrence of TBI-induced chronic neuropathic pain.
Key Words: Traumatic brain injury; Brain-derived neurotrophic factor; Mechanical allodynia; Neuropathic pain; Intrathecal dexmedetomidine; Propofol
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