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Korean J Anesthesiol > Volume 72(4); 2019 > Article
Lee, Ng, Teo, and Wong: Use of a trans-tracheal rapid insufflation of oxygen device in a “cannot intubate, cannot oxygenate” scenario in a parturient -a case report



The trans-tracheal rapid insufflation of oxygen (TRIO) device is less commonly used and is an alternative to trans-tracheal jet ventilation for maintaining oxygenation in a “cannot intubate, cannot oxygenate” (CICO) scenario.


We report the successful use of this device to maintain oxygenation after jet ventilator failure in a parturient who presented with the CICO scenario during the procedure for excision of laryngeal papilloma.


A stepwise approach to the airway plan and preparation for an event of failure is essential for good materno-fetal outcomes. The TRIO device may result in inadequate ventilation that can lead to hypercarbia and respiratory acidosis. Hence, it should only be used as a temporizing measure before a definitive airway can be secured.

Trans-tracheal jet ventilation is an established temporizing method of oxygenation in a “cannot intubate, cannot oxygenate” (CICO) scenario. However, trans-tracheal rapid insufflation of oxygen (TRIO) through a cricothyroidotomy cannula is a less familiar yet effective alternative and is readily available in Singapore General Hospital [1]. We describe its successful use in an emergency situation, for maintaining oxygenation after unexpected jet ventilator malfunction in a CICO scenario in a parturient.

Case Report

A 35-year-old parturient, at 13 + 1 weeks of gestation, was scheduled for an elective surgical excision of a recurrent laryngeal papilloma (Fig. 1). In the preoperative clinic, flexible nasoendoscopy showed large papillomatous lesions obscuring the glottic inlet. The patient was breathing well, albeit with mild stridor. She was strongly advised to undergo an awake tracheostomy under local anesthesia, as it was deemed the safest option. However, she adamantly refused as she was extremely anxious, and reported that she had previously undergone a similar operation without the need for a tracheostomy. An awake rigid Bonfils (Karl Storz GmbH & Co. KG, Germany) fiberoptic intubation was previously used to secure the airway. Using this technique again was considered unsuitable due to the extent of the laryngeal lesions. The following alternative strategy, which she agreed to, was offered: plan A - inhalational induction and oral Bonfils intubation; plan B - oxygenation by jet ventilation via needle cricothyroidotomy as a temporizing measure; and, plan C - asleep tracheostomy.
One week later, on the day of surgery, all airway equipment was checked including the TRIO device (Fig. 2), which is our institution’s version of the Rapid-O2 TM (Meditech Systems, Ltd., UK) [1]. The patient’s neck anatomy was marked out, and a senior consultant ENT surgeon was scrubbed and available to perform an emergency tracheostomy, should the need arise.
Standard anesthetic monitoring was applied, and her SpO2 was 95% in room air. Inhalational induction was performed with sevoflurane 6% in 100% oxygen. At 2.0 MAC (minimum alveolar concentration), the patient still exhibited spontaneous arm movements. At 2.2 MAC (10 min after the start of induction), she developed severe airway obstruction with a depressed capnography waveform, but her SpO2 remained at 100%. We proceeded with plan B, i.e., Ravussin cannula (VBM Medizintechnik GmbH, Germany) cricothyroidotomy whilst maintaining face mask oxygenation. She then developed complete airway obstruction with absent capnography waveform accompanied by paradoxical chest/abdominal movement after we successfully obtained front of neck access. This was initially relieved by face mask ventilation but became progressively difficult to manage. In anticipation of a CICO scenario, we immediately administered 70 mg rocuronium and planned to start jet ventilation. However, our Monsoon (Acutronic Medical Systems AG, Switzerland) jet ventilator unexpectedly malfunctioned despite being fully operational during the pre-induction check. Face mask ventilation became impossible, and her SpO2 dropped to 70%. The TRIO device was connected to the Ravussin cannula with an oxygen flow of 15 L/min, and the lungs were insufflated for 4 s [1]. The lowest SpO2 was 63%, but rapidly reached 100%.
A single attempt at oral Bonfils intubation was performed with simultaneous McCoy laryngoscopy by the most senior consultant anesthetist, but this failed due to distorted anatomy. The ENT surgeons proceeded with an emergency tracheostomy creation which took thirty minutes due to the presence of an undetected goiter. During this time, ten “breaths” of intermittent oxygen insufflation (each lasting 2 s) via the TRIO device was administered to keep the SpO2 at 95%–100%. Arterial blood gas revealed pH 6.935, pCO2 130 mmHg, and pO2 136 mmHg. We considered converting the Ravussin cannula to a cuffed tube to optimize carbon dioxide clearance, but this was not required as the tracheostomy was completed soon after. Surgery proceeded uneventfully, and a postoperative obstetric review indicated no concerns with regard to the pregnancy. The tracheostomy was decannulated the next day, and the patient was discharged on the second postoperative day.


We accept that some instances of our decision making may be considered controversial, but this report highlights the potential conflict in the process of consent-taking between patient autonomy and the clinician’s judgement to provide the best and safest treatment option. In our case, the patient refused an awake tracheostomy, which was strongly conveyed to her as the safest option. We therefore opted to secure her airway after induction of anesthesia, as the consultant was an airway specialist with considerable experience in managing similar airway lesions and agreed with the patient on an alternative and acceptable airway strategy. Plan A was gas induction of anesthesia and Bonfils intubation. Plan B was to maintain oxygenation using high frequency jet ventilation via a needle cricothyroidotomy which would have allowed time for plan C (asleep tracheostomy). Our case emphasizes several key points: airway obstruction can worsen rapidly during inhalational induction; rescue of a CICO scenario with a TRIO device; and, the need for backup devices. We discuss the rationale behind our airway strategy.
Awake, flexible, fiberoptic intubation should be avoided in cases of severe airway obstruction, as complete obstruction can result from sedation and airway topicalization [2,3], and from the fiberscope passing through the obstructive lesion, causing a “cork-in-a-bottle” scenario [4]. The next best option was inhalational induction of anesthesia, as it preserves spontaneous respiration. Should complete airway obstruction occur, cessation of the volatile agent will theoretically allow the patient to wake up, although decreased ventilation would increase the time needed [4]. However, the required deep level of anesthesia for intubation precipitated worsening of the airway obstruction in our patient, and face mask ventilation became extremely difficult.
We proceeded on to plan B i.e., oxygenation via needle cricothyroidotomy using high frequency jet ventilation, a temporizing measure to provide time for a more controlled tracheostomy. A pre-induction insertion of a cricothyroidotomy cannula would have been ideal but was not performed because of patient refusal. We chose to use the Monsoon jet ventilator as it has been safely used in cases of upper airway obstruction because it minimizes barotrauma by automatically pausing jet ventilation if the pre-set airway pressure limit (“pause pressure”) is exceeded. Unfortunately, in our case, the Monsoon ventilator failed due to a software problem.
After encountering a potential CICO scenario, we paralyzed our patient with rocuronium, with sugammadex readily available to reverse paralysis if required. This is controversial, as it causes loss of muscle tone, ablates spontaneous ventilation, and diminishes the ability to awaken the patient [4]. In severe, fixed, annular tracheo-bronchial obstructive lesions, administering muscle relaxants can improve ventilation through the application of positive pressure ventilation [5]. In contrast, with pedunculated lesions, there is a risk for a ball-valve like obstruction if muscle relaxants are given and positive pressure ventilation is applied [4]. However, the latest difficult airway guidelines recommend the use of muscle relaxants in a CICO scenario, as it may reverse laryngospasm and optimize mask ventilation and laryngoscopy [6]. In addition, it may reduce the risk of negative pressure pulmonary edema caused by forceful spontaneous ventilation in the presence of an obstructed upper airway [7]. Moreover, awakening the patient was not an option because of severe hypoxia, and the higher time needed for sevoflurane redistribution to permit awakening [8].
We salvaged the CICO scenario by rapidly oxygenating the patient using the TRIO device via the needle cricothyroidotomy. Previously known as the “Leroy,” this device consists of two pieces of oxygen tubing linked by a thumb operated Y-piece that allows controlled insufflation of the lungs (“breaths”) at 15 L/min [1,9]. The underlying principle is of provision of oxygenation with carbon dioxide clearance being secondary while minimizing the duration and rate of insufflation to reduce the risk of barotrauma [9]. High pressures of up to 4,000 cmH2O are generated from the oxygen flowmeter, which is directly transferred to the airways, resulting in high intrathoracic pressures in the event of significant or complete upper airway obstruction [10]. Upon obtaining tactile feedback of high pressure via the thumb during Y-piece occlusion, the user can terminate lung insufflation, acting as a safety mechanism against barotrauma. In trials involving live sheep models, Heard et al. established that an initial “breath” of 4 s delivering 1,000 ml of oxygen is sufficient to restore oxygenation [10,11]. Release of the Y-piece then allows passive expiration of gases. Exhalation of a tidal volume of 500 ml takes at least 30 s via the 14 G cannula [12]. However, is likely to be longer in case of upper airway obstruction. If more “breaths” are delivered prior to expiration, barotrauma may result. Hence, subsequent “breaths” of 2 s (delivering 500 ml oxygen) are delivered when there is inadequate initial SpO2 response or a SpO2 drop of 5% from the maximal SpO2 attained after the initial insufflation attempt [10,11]. The rate of insufflation can be low because oxygen saturation takes at least a minute to fall following an insufflation [11]. Allowing adequate time for lung deflation is more crucial than lung insufflation to minimize barotrauma [13]. The shortest duration for insufflation and longest duration for exhalation should be used.
In contrast, some jet ventilators do not have an expiratory valve, potentially contributing to gas trapping, hypoventilation, and an increased risk of barotrauma in cases of complete airway obstruction [14]. Peak airway pressures are also lower with insufflation devices such as the TRIO, compared to manual high-pressure jet ventilators [15]. However, restoration of normal oxygen saturation may lag behind insufflation of lungs by up to 20 s. As this is primarily an oxygenation device, it should be noted that inadequate ventilation from prolonged expiration and low insufflation rates can also cause hypercarbia and respiratory acidosis. End-tidal capnography is not reliable during TRIO. There have been no studies on the maximum duration of maintaining oxygenation with the TRIO device. However, severe respiratory acidosis has deleterious systemic effects such as cardiovascular instability and increased intra-cranial pressure. As such, the TRIO device should be used as a temporizing measure for oxygenation in a CICO scenario while attempts are made to secure a definitive airway (e.g., tracheostomy) to allow adequate ventilation and oxygenation.
We attempted oral intubation using the rigid Bonfils fiberscope, as it is a slim optical stylet with an anteriorly curved tip that can be manipulated around obstructive peri-glottic lesions, facilitating tracheal intubation. We used it in conjunction with laryngoscopy with the McCoy blade as its levering tip lifts the epiglottis and displaces lesions anteriorly, improving the visualization of the glottis. This was not successful, and the surgeons proceeded with the creation of a tracheostomy.
A patient’s autonomy may conflict with what is considered the best and safest treatment option in patients with an anticipatedly difficult airway. A logical and stepwise airway plan is therefore required. Alternative equipment should be available and plans in place in case of unexpected equipment failure. The TRIO device is an inexpensive device that can be readily available in every operating theatre to allow for prompt rescue of a CICO scenario.


Conflicts of Interest

No potential conflict of interest relevant to this article was reported.

Author Contributions

John Lee (Conceptualization; Writing–original draft; Writing–review & editing)

Von Vee Ng (Conceptualization; Writing–original draft; Writing–review & editing)

Constance Teo (Conceptualization; Writing–review & editing)

Patrick Wong (Conceptualization; Supervision; Writing–original draft; Writing – review & editing)

Fig. 1.
Laryngeal papilloma.
Fig. 2.
Trans-tracheal rapid insufflation of oxygen (TRIO) device.


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