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Korean Journal of Anesthesiology 1980;13(2):135-139.
DOI: https://doi.org/10.4097/kjae.1980.13.2.135   
Epilural Morphine in Treatment of Caneer Pain .
Myung Sook Kim, Joo Sik Yoon, Mi Yun Kim, Kyo Sang Kim, Heung Dae Kim, Yung Suk Kim, Dong Ho Park, Wan Sik Kim
1Department of Anesthesiology, Seoul Adventist Hospital, Korea.
2Department of Anesthesiology, Hanyang University College of Medicine, Seoul, Korea.
Epidural injection of 2.0 mg morphine with distilled water or 0.9 % normal saline 10 ml were given to a bladder cancer patient with severe chronic intraetable pain which radiated from low abdomen to gluteal and low leg region. The patient had absolute pain relief which began 2~3 minutes to onset, with 3~5 minutes of peak of action and was effective for 20~25 hours (mean 24 hours) without complications or continuous care as an ambulatory patient. It is suggested that the morphine reached the subarachinoid space through the membrane and produced its effect by direct action on the specific opiate receptors in the substantia gelatinosa of the posterior horn of the spinal cord.


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