A large SCT was detected by ultrasound in the fetus of a 27-year-old primagravida, with an unremarkable past medical history, at 25 weeks and 5 days of gestation. Because of preterm labor, the mother underwent an emergency cesarean section at 32 weeks and 2 days of gestation. The infant weighed 2.8 kg, with 1 and 5 minutes Apgar scores of 3 and 6, respectively. The patient was intubated and high frequency ventilation was required for poor respiration. Postnatal ultrasonography confirmed the presence of a highly vascular type 2 teratoma, 10 × 20 × 19 cm in size, extending to the pelvic and abdominal cavities, and containing solid and cystic components. There was also evidence of hydrops fetalis, including subcutaneous edema and severe abdominal ascites, and grade 4 hydronephrosis in both kidneys. Following a cystostomy, urine output was maintained at about 3-3.5 ml/kg/hr.

Preoperative laboratory results were as follows; hemoglobin 11 g/dl, hematocrit 33%, platelet 230 × 10³/µl, prothrombin time 1.01 INR and activated partial thromboplastin time 38.4 seconds. Other electrolytes were within normal range (Table 1). Electrocardiogram (ECG) and chest x-ray were normal, but preoperative echocardiogram showed patent ductus arteriosus with left to right shunt, but revealed no congestive heart failure. On day 2 after birth, she was placed on a high frequency ventilation with improvements in her arterial blood gas analysis (ABGA). Thus, mechanical ventilator setting was changed to a synchronized intermittent mandatory ventilation mode. Surgery was scheduled on day 3 after birth. The patient arrived in the operating room without premedication. ECG, non-invasive blood pressure and oxygen saturation were monitored throughout. Anesthesia was induced with intravenous fentanyl (2 µg/kg) and vecuronium (0.1 mg/kg) and maintained with 0.5 vol% isoflurane, a 30% oxygen/air mixture, and a continuous infusion of fentanyl (2 µg/kg/hr). A 4-French central venous catheter (Arrow International, Inc, Pennsylvania, USA) was inserted into the left internal jugular vein to monitor central venous pressure and fluid replacement, and a 20-gauge peripheral intravenous line was inserted into the left antecubital area. A 24-gauge arterial catheter was inserted into the right brachial artery for continuous monitoring of arterial blood pressure and frequent ABGA. Since an intra-abdominal tumor would make ventilation difficult, surgeon performed an abdominal incision and decompression. Ventilator was set to a pressure control mode with peak inspiratory pressure of 25 mmHg, tidal volume of 30 ml and respiratory rate of 30 breaths/min. The patient was placed in the prone position for excision of sacrococcygeal mass. Temperature maintained at 35.5-37.0℃ using a force warming device and an intravenous fluid warmer. Bleeding continued during surgery, with hemoglobin concentration declining to 6.1 g/dl and hematocrit to 18%, requiring aggressive transfusion with packed red blood cells (pRBCs). The pRBCs, fresh-frozen plasma (FFP) and platelet concentrates (PC) were transfused throughout the procedure. About 2 hours later, adequate ventilation was maintained. An arterial partial pressure of oxygen was 118 mmHg and oxygen saturation was 100% on 30% mixed with medical air. Following the dissection of the posterior aspect of tumor, which was 2 hours and 40 minutes after induction, the patient was placed in the supine position for manipulation of the abdominal mass. During resection of the abdominal mass, respiratory ventilation was difficult because the tumor pressed onto the chest. Peak inspiratory pressure was increased to 35 mmHg, and tidal volume was reduced to 15 ml. Therefore, we frequently had to ventilate manually. Also, ABGA showed hypoxemia, hypercarbia and respiratory acidosis (Table 1). After repeating this process for about 20 minutes, there was a sudden hypotension and ventricular fibrillation on ECG followed by extreme bradycardia and asystole. At the time of the cardiac arrest, body temperature was 37.0℃. Resuscitation was successfully performed with external cardiac massage, repeated injections of epinephrine 10 µg, and continuous infusion of dopamine (5 µg/kg/min). During resuscitation, ABGA showed severe hyperkalemia with a value of 11.6 mmol/L (Table 1), which was managed by repeated injections of calcium gluconate 30 mg and sodium bicarbonate 3 mEqL and continuous infusion with regular insulin (0.4 u/hr). The total duration of cardiac arrest was 30 minutes. Mean arterial pressure was maintained at 40-50 mmHg during resuscitation. Following resuscitation, the surgeons decided to proceed with the operation. The patient's potassium level decreased to 8.7 mmol/L, but remained high (Table 1). The total operation time was 5 hours, during which the patient received a total of 230 ml normal saline, 580 ml pRBCs, 240 ml FFP, and 40 ml PC. Urine output gradually decreased during surgery, with a total urine output of 25 ml.

The patient was transferred to the neonatal intensive care unit (NICU) in relatively stable condition, except for poor urination. In the NICU, however, intra-abdominal bleeding continued because of disseminated intravascular coagulation, and the patient required pRBCs, FFP and PC. Despite regular infusions of insulin, she showed persistent hyperkalemia (Table 1) accompanied by oliguria, suggesting a congenital urinary tract anomaly such as urethral malformation or obstruction. The patient's heart rate and blood pressure gradually decreased, leading to cardiovascular collapse. Despite prolonged cardiac massage for about 2 hours, the patient died. A pathological examination confirmed the diagnosis of SCT, with a malignant mixed germ cell tumor.

A large mass, measuring about 15 × 13 × 10 cm, was detected by ultrasound in the fetus of a 30-year-old primagravida at 26 weeks and 3 days of gestation. Radiofrequency ablation was performed in utero at 31 weeks and 1 day of gestation, but the size of the tumor was not markedly reduced. Prenatal ultrasound showed no evidence of hydrops fetalis or other anomalies. Because of the premature rupture of membranes, the mother underwent an emergency cesarean section at 35 weeks and 5 days of gestation. The baby weighed 3.7 kg, with 1 and 5 minutes Apgar scores of 6 and 9, respectively. Ulceration and bleeding were seen on the surface of the SCT (Fig. 1), but hyperkalemia did not developed.

Preoperative laboratory results, ECG, chest x-ray and echocardiogram were normal. Surgery was scheduled on day 3 after birth. In the operating room, the patient was monitored by ECG, non-invasive blood pressure and oxygen saturation. Anesthesia was induced with 2 µg/kg fentanyl and muscle relaxation was achieved with 0.1 mg/kg vecuronium. General anesthesia was maintained with sevoflurane at 0.5 vol% and a continuous infusion of fentanyl (2 µg/kg/hr). A 5-French central venous catheter (Arrow International, Inc, Pennsylvania, USA) was inserted into the right internal jugular vein to monitor central venous pressure and administer fluid, and a 22 gauge peripheral intravenous line was inserted into the right antecubital area. A 24 gauge arterial catheter was inserted into the right brachial artery for continuous arterial blood pressure monitoring and frequent ABGA. The patient was then placed in the prone position for the procedure, because the mass was located in the sacrococcygeal area. After positioning, ABGA showed normal values (Table 2), which confirmed adequate ventilation. Temperature was maintained at 35.5-36.5℃ using a force warming device and an intravenous fluid warmer. During operation, bleeding continued, with hemoglobin levels dropping to 5.4 g/dl and hematocrit to 16%, requiring aggressive transfusion of pRBCs. The pRBCs, FFP, PC and cryoprecipitate were transfused throughout the procedure. Two hours after skin incision, the patient's heart rate dropped from 140 bpm to below 80 bpm and blood pressure suddenly dropped from 58/37 mmHg to 28/15 mmHg. At the time of the circulatory collapse with marked bradycardia, body temperature was 36.1℃. Resuscitation was successfully performed with external cardiac massage and repeated injections of epinephrine 10 µg and atropine 20 µg. During resuscitation, ABGA showed severe metabolic and respiratory acidosis and hypocalcemia, but potassium concentration was within normal limits (Table 2). The duration of cardiac massage was about 1 min, after which the surgeons decided to proceed with the surgery. The total duration of the operation was 5 hours, during which the patient received a total of 100 ml normal saline, 40 ml lactated Ringer's solution, 660 ml pRBCs, 120 ml FFP, 240 ml PC and 40 ml cryoprecipitate. Total urine output was 34 ml. The patient was transferred to the NICU in a stable condition. She was extubated on postoperative day 6 and discharged home in good condition on postoperative day 17. A pathological examination confirmed the diagnosis of SCT, consisting of an immature teratoma without malignant cells.