Case Report
A 81-year-old woman (height: 150 cm, body weight: 49 kg) was admitted to an intensive care unit because of respiratory failure and generalized edema. She was followed up in our hospital because of hypertension, congestive heart failure, asthma and a destroyed lung due to having pulmonary tuberculosis for 9 years. She was admitted in an intensive care unit and she received controlled mechanical ventilation because of the aggressive generalized edema and respiratory failure caused by the corpulmonale and congestive heart failure. The controlled ventilation was maintained with a tidal volume of 380-440 ml, a respiratory rate (RR) of 16-24 bpm and an FiO
2 of 35% and a positive end expiratory pressure (PEEP) of 5 cmH
2O. She developed tracheomegaly during the 53 days of mechanical ventilation. She was impossible to wean off the mechanical ventilator, so she was planned to undergo tracheostomy. On the chest radiography, the maximum transverse diameter of the trachea was measured to be 50.3 mm (
Fig. 1); on the thoracic CT, the maximum diameter of the trachea was measured to be 51.3 mm and 48.8 mm, respectively, in the sagittal and transverse directions (
Fig. 2).
The patient was premedicated with 0.2 mg of glycopyrrolate IM at 30 minutes pre-op. She was transported in the operating room and her trachea was intubated with a 6.5 mm internal diameter endotracheal tube. We connected the breathing circuits and the endotracheal tube, we monitored the electrocardiography and performed noninvasive blood pressure monitoring, pulse oximetry and capnography. At arrival in the operation room, the patients was drowsy and her vital signs were blood pressure: 130/80 mmHg, heart rate: 130 rate/min, O2 saturation: 72% and end-tidal carbon dioxide (ETCO2): 56 mmHg. After hyperventilation by using ambu-bagging with 100% O2 6 L/min, the O2 saturation and ETCO2 reached 95-96% and 43-46 mmHg respectively.
Anesthesia was induced with 5 mg of midazolam IV and 15 mg of rocuronium bromide IV after loss of conscienceness and the 0.05-0.1 µg/kg/min of remifentanil was continuously infused. Anesthesia was maintained with sevoflurane 1-1.5 Vol%, The FiO2 was 60%, and fresh oxygen was given at 4 L/min. Pressure controlled ventilation via a ventilator (Cato® edition, Dräger Medical AG, Germany) was provided with a peak airway pressure of 25 mmHg, The RR was 15-20 bpm and the PEEP was 5 cmH2O. After tracheostomy, we extubated the endotracheal tube and then a 7 mm cuffed tracheostomy tube was inserted. We inflated the cuff with 10 ml air via a pilot balloon of the tracheostomytube, but tidal volume was very small because of the significant peritubal leakage during the ambu-bagging. Despite of inflating the cuff with 15 ml air via a pilot balloon, after the 8 mm tracheostomy tube re-intubated, we couldn't control the ventilation because of peritubal air leakage. The ETCO2 continued to increase to 55-60 mmHg.
The arterial blood gas showed severe hypercapnia: pH 7.09, PaCO2 97.2 mmHg, PaO2 78 mmHg and HCO3- 29.7 mEq/L. We observed the nasal and oropharyngeal air leakage, so we compressed the above site of the thyroid cartilage and we then confirmed the reduced air leakage. We packed the larynx with wet gauze using an intubating blade and forceps to prevent gas leakage. But the tidal volume was 100-150 ml and air leakage was still present. To preventing laryngeal air leakage, we intubated with a 4 sized Proseal® laryngeal mask airway after sealing the connector with tape. We could control the ventilation as the the air leakage was reduced and tidal volume was more than 200 ml, so we brought the patient back to consciousness with 100% oxygen. At this point, the patient's vital signs were: blood pressure: 100/70 mmHg, heart rate: 100-110 rate/min, O2 saturation: 95-96%, ETCO2: 43 mmHg. But as the patient awoke and she recovered her laryngeal reflex, the laryngeal mask airway was displaced, so we couldn't controlled the ventilation. Once more the ETCO2 increased to 55-60 mmHg, and we planned endotracheal reintubation. After IV midazolam 3 mg and remifentanil 60 µg, the tracheostomy tube was extubated. We intubated her with a 6.5 mm endotracheal tube and inflated the cuff to 25 cmH2O with a cuff pressure manometer (VBM Medizintechnik GmbH, Germany). The endotracheal tube depth was 23 cm at the patient's upper lip. Chest auscultation revealed symmetrical and little air leakage was present. But the tidal volume measured over 300 ml for ambu-bagging. The incision site of the tracheostomy was sutured. After hyperventilation with ambu-bagging, the ETCO2 measured 38-42 mmHg. The arterial blood gases were a pH of 7.29, a PaCO2 of 46.2 mmHg, a PaO2 of 78 mmHg and a HCO3- of 29.7 mEq/L. The patient's vital signs were a blood pressure of 105/40 mmHg, a heart rate of 105 beats/min and an O2 saturation of 97%. The patient was moved ICU with ambu-bagging while she was unconscience.
Discussion
Tracheomegaly was first recognized at autopsy by Czyhlarz in 1897, but it was not until 1932 that Mounier-Kuhn associated the endoscopic and radiographic appearances [
2]. In Korea, tracheobronchomegaly with multiple diverticula was first reported by Park et al. in 1993 [
3]. Tracheomegaly is diagnosed when the transverse diameter of the trachea is greater than normal and exceed 25 mm and 21 mm in men and women, respectively. The internal transverse diameter of the trachea is measured 2 cm above the top of the aortic arch on the posteroanterior chest radiographs [
4]. Normally, the transverse diameter measures 13-25 mm in men and 10-21 mm in women. On simple chest radiographs, we identified the increased diameter of the central trachea, which is more easily observed on the lateral view than the posteroanterior view. The diameters of the trachea 2 cm above the top of the aortic arch, the right main bronchus and left main bronchus that exceed 3 cm, 2.4 cm and 2.3 cm respectively, on the standard chest radiographs or bronchogram are diagnostic of tracheobronchomegaly. For chest CT, these values are 3.0 cm, 2.0 cm and 1.8 cm, respectively [
3]. In this report, the maximum transverse diameter of the trachea was measured to be 50.3 mm on chest radiography (
Fig. 1). For chest CT, these values are 51.3 mm and 48.8 mm, respectively, in the sagittal and transverse directions (
Fig. 2). The transverse diameters of the right and left main bronchi were 1.5 cm and 1.3 cm, respectively, and this wasn't appropriate for tracheobronchomegaly.
The symptoms of tracheomegaly are nonspecific with fever, chilling, cough and sputum production secondary to bronchiectasis and lower respiratory infection. The grossly enlarged, but weakened airways and inefficient cough mechanisms block mucocilliary clearance leading to mucous retention with resultant recurrent pneumonia, bronchiectasis and fibrosis. Excessive sputum production with occasional hemoptysis occurs and the patients may develop dyspnea and respiratory failure as the lungs become progressively damaged. In addition, spontaneous pneumothorax, hemoptysis, pneumonia and finger clubbing may develop [
5]. The pulmonary function tests reveal an obstructive pattern and restrictive ventilatory impairment when the fibrosis progresses. In this case, the pulmonary function tests were not obtained because the patient had received mechanical ventilation since her admission. Tracheomegaly should be diagnosed before an operation, but it can appear in patients with no symptoms and because the air leaks a lot during the induction of anesthesia induction from a patient who has previously received radiation therapy to the head and neck. There has been a case in which the doctor discovers tracheomegaly after excluding injury due to the cuff or other problems during recurrent intubation [
6]. Thus, the anesthesiologist must consider the problems of respiratory tract, including tracheomegaly, for patients with these types of medical histories.
The etiology of this is various. Autopsy studies have suggested a congenital defect or atrophy of the elastic and smooth muscle tissues of the trachea because of the reports of associated connective tissue disease such as Ehlers-Danlos syndrome and dermatochalasis [
4]. However, some physicians have suggested tracheomegaly's secondary development by ventilator therapy, barotrauma, smoking and chronic irritants because most patients have no other connective tissue abnormality and tracheomegaly is discover after the second decade of life [
7]. Acquired tracheomalacia may be caused by pressure necrosis, impairment of the blood supply, infection and the cyclic friction on the dry tracheal mucosa during prolonged endotracheal intubation. Some may develop tracheomegaly [
8]. In this case, our patient developed tracheomalacia from the recurrent inflammation and infection due to chronic bronchitis and emphysema. During the mechanical ventilation, pressure on the tracheal wall during prolonged endotracheal intubation would help develop the secondary tracheomegaly.
It is said that tracheomegaly frequently occurs when the period of pulmonary fibrosis is long and the respiratory pulmonary disease is severer, and the main mechanism for the occurrence of tracheomegaly with diffuse pulmonary fibrosis is the traction on the tracheal wall [
9]. The prevalence factor of tracheal traction that increases the is the increase in the elastic recoil pressure that occurs due to the abnormal increase of the fibrosis tissue at the lung parenchyma. Pulmonary fibrosis does not invade the respiratory tract itself, but rather, it increases the elastic recoil pressure, and so it pulls the respiratory tract and causes tracheomegaly [
4]. Tracheal stenosis also causes tracheomegaly with the increase of the elastic recoil pressure for the triggers of the tracheal traction [
9]. This may cause tracheal stenosis or aggravation of tracheomegaly as a complication of endotracheal intubation for tracheobronchomegaly, while reporting the increase in enlarged trachea after intubating, using the tube with cuffs for the patient who suffers from tracheobronchomegaly, so Messahel said that, in case mechanical ventilator therapy is needed, the method to charge the throat with wet gauze to reduce the leakage of anesthesia gas and danger of inhalation and to use the endotracheal tube with no cuff is recommended [
10]. However, Bourne, et al used the endotracheal tube of a bit larger diameter with cuffs for the patient with abnormally large diameter of trachea because, although the cuff is inflated in maximum in case the diameter of trachea is considerably large, there is a danger of pulmonary aspiration due to severe air leakage around the cuff [
11]. According to the report of intubation for general anesthesia of other patients of tracheomegaly abroad, 9.0 mm endotracheal tube was used for the patient whose transverse diameters are 34 mm by standard chest radiography and 18 ml of air was inflated into the cuff for the air not to leak around the cuff so that operation worked well [
12].
The patient of this case had maximum diameter of trachea, which was 51.3 mm by chest CT. According to the report by Balakrishnan et al., who measured tracheal diameter by chest CT targeting 5,324 patients who had abnormal simple chest radiography and respiratory problem, the patient had very large diameter of trachea comparing with the maximum diameter of trachea 35.72 mm of the patient who had the largest trachea [
13]. Owing to this, the patient of this case was impossible to controlled ventilation by inflating the cuff simply due to the severe air leakage. However, the control of ventilation was possible by fixing through the spot which passed the broadest space of the trachea but not passing the carina, utilizing the fact that tracheomegaly was not severe 2-3 cm up from the carina. However, general tracheostomy tubes of 7 mm and 8 mm are limited in intubation depth by 80 mm and 90 mm in total. After all, the patient got severe hypercapnia by planning the surgery, not perceiving the necessity of a longer tracheostomy tube.
Besides its average size, the tracheostomy tube is commercialized by extra-long one (TRACOE® medical GmbH, Germany). In case of 7 mm, 8 mm tracheostomy tubes, the total lengths are 104 mm, 120 mm, and in case of 10 mm tracheostomy tube, the total length is 135 mm. Long tracheostomy tube is needed when there is anatomic abnormality such as a very thick neck or tracheal stenosis or enlargement, but it is seldom used, so the hospital usually doesn't have it. As the patient is limited in movement of neck, Hydri et al., has reported the method to use while transforming the endotracheal tube and, although there may be methods to use by intubating the endotracheal tube in the tracheostomy incision site until these patients secure long tracheostomy tube, it has no good appearance and has concerns of extubation [
14].
This hospital also could make a long tracheostomy tube which has modified endotracheal tube while connecting endotracheal connector, cutting the disposable oxygen mask, and inserting neck flange into the endotracheal tube after cutting the inflation line which swells the pilot balloon of the endotracheal tube by deciding the size for the patient not being damaged (
Fig. 3). Modified tracheostomy tube is longer than the general ones, and is surely shorter than the endotracheal tube (
Fig. 4).
In this case, it has considered intubating the endotracheal tube during the surgery instead of tracheostomy tube, but it was not attempted, considering the high risk of extubation by unstable fixation of endotracheal tube and the endotracheal tube being long. Through this case, the modified tracheostomy tube reformed by this endotracheal tube is thought as an excellent substitute until the long tracheostomy tube is secured during the emergency.
This case was diagnosed as tracheomegaly, but after tracheostomy, it has not predicted the situation that it isn't ventilated as a general tracheostomy tube, and it was a considerably embarrassing experience of a view on hypercapnia and acidosis. In case of patient of general tracheomegaly, as the size of the trachea was not severe, could managed the airway only by inflating the cuff. But, as in this case, there may be a situation at which the airway cannot be managed only by inflating the cuff for the patient of very large tacheomegaly. Also, in case of regular tracheostomy tube, its length is limited, so the length of intubation is uncontrollable.
So, when planning the surgery of a patient with tracheomegaly, enough consideration for the diameter of trachea at the spot where endotracheal tube and tracheostomy tube are located will be needed. A longer tracheostomy tube, which has modified endotracehal tube mentioned at this case, may be of help in managing the airway by the anesthegiologist when a long tracheostomy tube is needed in emergency for the patient who has anatomic abnormality of the respiratory tract unpredicted such as tracheomegaly, thick neck and tracheal stenosis, which are not diagnosed yet.