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Korean Journal of Anesthesiology 2008;54(6):635-639.
DOI: https://doi.org/10.4097/kjae.2008.54.6.635   
The Change of the Serum Potassium [K+] Level with the Use of Graft Preserved UW Solution or HTK Solution before and after Reperfusion in Liver Transplantation Recipients.
Jeong Rim Lee, Kook Hyun Lee, Seng Sim Bae, Tae Kyong Kim, Choon gun Ryu
Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, Korea. manya1@hanmail.net
In liver transplantation, an increase of serum potassium [K+] after reperfusion is related to components of the preservation solution. However, the histidine-tryptophan-ketoglutarate (HTK) solution, which is now popularly used, has a twelve times lower [K+] as compared to the UW solution. This retrospective study was performed to compare the use of the UW solution with the HTK solution for changes in the serum [K+] during the early reperfusion period in liver transplantation recipients.
Anesthesia medical records of 366 liver transplant patients were reviewed and patients were enrolled in one of the two groups; recipients who received a transplanted liver preserved with the UW solution (UW group), and recipients received a liver preserved with the HTK solution (HTK group). Serum [K+] changes 5 min before, 5 min after, and 20 min after reperfusion for recipients in each group were compared.
In the UW group, [K+] increased 5 min after reperfusion and decreased 20 min after reperfusion as compared to [K+] 5 min before reperfusion (3.93, 4.07, and 3.76 mM in 5 min before, 5 min after, and 20 min after reperfusion respectively; P < 0.001). In the HTK group, [K+] significantly decreased 5 min and 20 min after reperfusion as compared to [K+] 5 min before reperfusion (4.12, 3.79, and 3.75 mM; P < 0.001).
When the HTK solution was used, the serum [K+] 5 min after reperfusion decreased as compared to the [K+] before reperfusion and didn't further decrease until 20 min after reperfusion.
Key Words: liver transplantation; potassium; preservative solution; reperfusion


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