| Acute liver injury after sevoflurane anesthesia: A case report. |
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Jong Taek Park, Young Bok Lee, Jong Soo Kim, Hoon Ryu, Hyun Kyo Lim |
1Department of Anesthesiology and Pain Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. hyunkyolim@yonsei.ac.kr
2Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea. |
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| Abstract |
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Halothane, isoflurane and desflurane are metabolized to hepatotoxic trifluoroacetyl proteins. But sevoflurane is metabolized to hexafluoroisopropanol. Hexafluoroisopropanol has a low binding affinity for liver protein and is therefore rapidly converted to glucuronidate that are excreted in the urine. Thus sevoflurane has been considered to have a very low potential for hepatotoxicity. We report a case of a 67 years old woman who developed acute hepatic dysfunction after sevoflurane anesthesia. |
| Key Words:
Hepatotoxicity; Sevoflurane |
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