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Korean J Anesthesiol > Volume 57(6); 2009 > Article
Korean Journal of Anesthesiology 2009;57(6):693-697.
DOI: https://doi.org/10.4097/kjae.2009.57.6.693   
The effects of lidocaine and fentanyl on airway irritability during inhalation induction with desflurane.
In Gyu Choi, Young Soon Choi, Jin Hye Min, Yong Ho Kim, Young Keun Chae, Woo Kyung Lee, Yong Kyung Lee, Ae Re Lee, Hyong Rae Cho, Hong Seok Chae
1Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea. jhmin@kwandong.ac.kr
2Department of Anesthesiology and Pain Medicine, Yonsei University, College of Medicine, Seoul, Korea.
Abstract
BACKGROUND
Inhalation induction with desflurane can cause airway irritability and sympathetic stimulation. The aim of this study was to investigate whether lidocaine and fentanyl could reduce these unwanted reactions. METHODS: Seventy-five patients who had premedication with midazolam were randomly allocated to one of three groups to receive intravenous saline (S group), lidocaine 1.5 mg/kg (L group), fentanyl 1 microgram/kg (F group), respectively, before tidal volume induction with desflurane in oxygen and nitrous oxide. We recorded airway irritability such as cough, apnea, laryngospasm and excitatory movement and hemodynamic changes. RESULTS: Airway irritability was not significantly different between the groups. In F group, mean blood pressure at LOC ver and LOC BIS and heart rate at LOC ver, LOC BIS and just before intubation were lower than those of S group (P < 0.05). Other results were not significantly different. CONCLUSIONS: The results of the study showed that intravenous fentanyl and lidocaine had no beneficial effects to reduce airway irritability, but intravenous fentanyl could significantly reduce hemodynamic stimulation during inhalation induction with desflurane in the patients who were premedicated with midazolam.
Key Words: Airway irritability; Desflurane; Fentanyl; Lidocaine; Midazolam


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