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Korean J Anesthesiol > Volume 57(6); 2009 > Article
Korean Journal of Anesthesiology 2009;57(6):742-748.
DOI: https://doi.org/10.4097/kjae.2009.57.6.742   
The effects of superior cervical ganglionectomy on the anxiety in the rats.
Eun Jung Cho, Hyo Seon Shim, Chong Min Park
Department of Anesthesiology and Pain Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. pcm@catholic.ac.kr
Abstract
BACKGROUND
Therapeutic indications for stellate ganglion block range from head and upper arm disease to general disease including psychosomatic disorders. The aim of this study was to evaluate the effects of superior cervical ganglionectomy on anxiety using the elevated plus maze test.
METHODS
Male Sprague-Dawley rats (150-250 g) were used. Each rat was put into the elevated plus maze 5 minutes per day for 10 days. We checked the number of entries into each arm (open arm and closed arm) and the duration of time staying in each arm. Rats were then divided into two groups: a group that received bilateral superior cervical ganglionectomy, and a control group that received a sham operation. The elevated plus maze test was then repeated and we evaluated the effect of superior cervical ganglionectomy on anxiety. RESULTS: Although there was an increased tendency of ganglionectomized rats to enter each arm, there were no significant differences in number of entries or in duration of stay between experimental and control groups.
CONCLUSIONS
Bilateral superior cervical ganglionectomy in rats does not reduce anxiety. However, further studies are needed, ones combined with neuroendocrine and clinical studies, to determine the effect of superior cervical ganglionectomy on behavioral responses.
Key Words: Anxiety; Stress; Superior cervical ganglionectomy; Sympathectomy
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