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Korean Journal of Anesthesiology 2007;52(4):461-464.
DOI: https://doi.org/10.4097/kjae.2007.52.4.461   
Intravenous Vitamin K-induced Cardiovascular Collapse : A case report.
Sang Jin Park, Chae Rim Seong, Dae Lim Jee
1Dalseong-gun Public Health Center, Korea.
2Department of Anesthesiology and Pain Medicine, Yeungnam University Medical Center, College of Medicine, Yeungnam University, Daegu, Korea. djee@medical.yeungnam.ac.kr
A cardiovascular collapse, due to preoperatively administered intravenous vitamin K (phytonadione), was experienced in a 59-year-old woman who was scheduled to undergo a left upper lung lobectomy. The patient developed sudden facial flushing, an upper torso rash, dyspnea, palpitation, and severe hypotension about 2 min after the intravenous administration of approximately 2 mg of vitamin K. Immediate hydration and an injection of 20 mg ephedrine restored her blood pressure to the preoperative level within 5 min. The patient recovered without any sequelae, but the operation was postponed. The patient's symptoms seemed to be due to an anaphylactoid reaction or anaphylaxis following the intravenous administration of vitamin K. This case report suggests that physicians should carefully review the indications of vitamin K prior to administration, even at low doses.
Key Words: anaphylaxis; cardiovascular collapse; vitamin K.


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