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Korean Journal of Anesthesiology 2007;52(5):561-565.
DOI: https://doi.org/10.4097/kjae.2007.52.5.561   
Comparison of Ramosetron and Ondansetron for Preventing Nausea and Vomiting after Gynecologic Surgery.
Jeong Hun Suh, Mae Hwa Kang, Jung Hee Ryu, Kum Suk Park, Sang Hwan Do
Department of Anesthesiology, Seoul National University College of Medicine, Seoul, Korea. shdo@snu.ac.kr
In this randomized, double-blinded study, we evaluated the efficacy of ramosetron and ondansetron for preventing postoperative nausea and vomiting (PONV) in gynecologic patients.
Sixty patients undergoing total abdominal hysterectomy or myomectomy, ASA physical status I or II, aged 30-65 yr, received IV ramosetron 0.3 mg (group R) or ondansetron 4 mg (group O) at the end of surgery (n = 30 each). A standard general inhalational anesthesia and postoperative IV patient-controlled analgesia were used. At postoperative 3, 24 and 48 hours, we assessed pain score (VAS), incidence of PONV, rescue drug consumption, adverse events associated with study medications and overall satisfaction scores.
The incidence of PONV showed no difference between groups at each time points after surgery (overall incidence; 59% in group R, 69% in group O). There was no difference in the severity of nausea, pain score and analgesic drug usage. However, the consumption of rescue drug in the ramosetron group was markedly less than that of ondansetron group at postoperative 3 hrs (none vs. 8 patients). No clinically serious adverse events were observed in either of the groups. Overall satisfaction scores were also comparable in both groups (6.5 +/- 3.0 vs. 6.2 +/- 2.7).
Prophylactic therapy with ramosetron is as effective and safe as conventional prophylactic therapy with ondansetron for preventing PONV in women undergoing general anesthesia for gynecologic surgery. Severity of PONV seems significantly less with ramosetron than with ondansetron in the early postoperative period.
Key Words: gynecologic surgery; ondansetron; postoperative nausea and vomiting; ramosetron


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