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Korean J Anesthesiol > Volume 52(5); 2007 > Article
Korean Journal of Anesthesiology 2007;52(5):609-611.
DOI: https://doi.org/10.4097/kjae.2007.52.5.609   
Clinical Experience with Recombinant Activated Factor VII in a Surgical Patient with Coagulation Factor VII Deficiency: A case report.
Sung Hwan Kim, Kyung Ji Lim, Seung Zhoo Yoon, Kum Suk Park, Sang Hwan Do
Department of Anesthesiology, Seoul National University College of Medicine, Seoul, Korea. shdo@snu.ac.kr
A 33-yr old female patient with coagulation factor VII deficiency was scheduled for laparoscopic oophorectomy under the diagnosis of ovarian teratoma. Plasma concentration of factor VII of this patient was 9 IU/dl (normal range; 60-140 IU/dl) and the prothrombin time INR (International Normalization Ratio) was 1.79 (normal range; 0.8-1.2) on the day before the operation. Total 1,200microgram (30microgram/kg) of recombinant activated factor VII (rFVIIa) was administered just before the start of the laparoscopic procedure, which was accomplished safely without severe hemorrhage or other complications. Postoperative course was uneventful. In addition, this article provides the clinical implication of rFVIIa in terms of hemostasis management in hemophiliacs and surgical patients.
Key Words: blood coagulation; coagulation factor VII deficiency; recombinant activated factor VII
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