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Korean J Anesthesiol > Volume 54(1); 2008 > Article
Korean Journal of Anesthesiology 2008;54(1):12-17.
DOI: https://doi.org/10.4097/kjae.2008.54.1.12   
The Effect of Doxapram Hydrochloride on Bispectral (BIS) Index and Recovery from Desflurane Inhalational Anesthesia.
Jong Taek Park, Young Bok Lee, Hyun Kyo Lim, Jae Chan Choi, Soon Yul Kim, Ja Youn Jeon, Kwang Ho Lee
Department of Anesthesiology and Pain Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. khl6006@yahoo.co.kr
Abstract
BACKGROUND
Doxapram hydrochloride is a respiratory stimulant that produces arousal effects in patients under anesthesia. We investigated the effects of doxapram on the recovery time and BIS index of patients administered desflurane inhalational anesthesia.
METHODS
40 patients who underwent general anesthesia using desflurane that had an ASA physical status of I or II received either 1 mg/kg of doxapram hydrochloride (doxapram group, n = 20) or normal saline (control group, n = 20) IV at end of surgery. Anesthetic recovery after the injection of doxapram was then determined based on the time to eye opening in response to verbal command, hand squeezing on command, time to extubation, and Aldrete recovery score. BIS index, systolic blood pressure, tidal volume and heart rate were recorded every minute for up to thirteen minutes.
RESULTS
The doxapram group showed significantly shorter times to emergence based on eye opening in response verbal command (sec) (409 +/- 114 vs 320 +/- 116), hand squeezing on command (sec) (458 +/- 119 vs 351 +/- 114) and extubation (sec) (491 +/- 103 vs 418 +/- 79) compared to control group. The BIS score was not significantly different between the two groups.
CONCLUSIONS
The Bis index was not significant higher in the doxapram group, with the exception of the measurement recorded at 2 minutes, however the recovery time from desflurane inhalational anesthesia was faster in the doxapram group than the control group.
Key Words: BIS; desflurane; doxapram chloride; recovery
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