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Korean J Anesthesiol > Volume 54(1); 2008 > Article
Korean Journal of Anesthesiology 2008;54(1):102-108.
DOI: https://doi.org/10.4097/kjae.2008.54.1.102   
Perioperative Combined Use of Sildenafil and Inhaled Iloprost for Moderate Portopulmonary Hypertension in a Patient Undergoing Liver Transplantation: A case report.
Duk kyung Kim, Hae Kyoung Kim, Jeong Ae Lim, Seung Min Jeong, Sung Whwan Jang, Ik Jin Yun
Departments of Anesthesiology and Pain Medicine, and *Surgery, Konkuk University Hospital, Konkuk University School of Medicine, Seoul, Korea. dikei@kuh.ac.kr
Abstract
Moderate to severe pulmonary hypertension, mean pulmonary arterial pressure (mPAP) > 35 mmHg, in cirrhotic patients is usually considered an absolute contraindication to orthotopic liver transplantation (OLT) because of unacceptably high mortality. We present the case of successful OLT in a cirrhotic patient with a mPAP of 42 mmHg and a pulmonary vascular resistance (PVR) of 298 dyne . sec . cm(-5) preoperatively. He was treated with oral sildenafil (Viagra(R)) and inhaled iloprost (Ventavis(R)) for 45 days and then his mPAP and PVR were reduced to 33 mmHg and 206 dyne . sec . cm(-5) at the time of transplantation. During OLT, his mPAP was stable of 28?38 mmHg with the combined use of sildenafil via a nasogastric tube and iloprost via a nebulizer. His hemodynamic parameters were stable and significant postoperative bleeding was not noticed throughout his stay in the intensive care unit. Thereafter, he was transferred to general ward without any cardio-respiratory problems on 7th postoperative days.
Key Words: iloprost; liver transplantation; sildenafil; pulmonary hypertension
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