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Korean J Anesthesiol > Volume 49(4); 2005 > Article
Korean Journal of Anesthesiology 2005;49(4):528-531.
DOI: https://doi.org/10.4097/kjae.2005.49.4.528   
Epinephrine-induced Metabolic Acidosis during Orthognatic Surgery: A case report.
Sang Beom Nam, Yon Hee Shim, Young Chan Park, Yong Bum Kim, Jong Seok Lee
Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea. jonglee@yumc.yonsei.ac.kr
Epinephrine has a variety of clinical uses one is its use as a topical hemostatic agent on bleeding surfaces, such as in the mouth. We report a temporal association between the administration of topical epinephrine and the development of metabolic acidosis during general anesthesia. A 21 year-old patient, with facial asymmetry, had undergone orthognatic surgery. During the operation, serial blood gas analysis revealed the onset of a metabolic acidosis following the local infiltration (0.036 mg) and topical application of a high dose of epinephrine-Bosmin(R) (1:1,000 epinephrine). The metabolic acidosis resolved within 5 hours.
Key Words: epinephrine; metabolic acidosis
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