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Korean Journal of Anesthesiology 2006;50(2):168-172.
DOI: https://doi.org/10.4097/kjae.2006.50.2.168   
Efficacy of Sufentanil during Laryngeal Microscopic Surgery.
Chul Ho Chang, Sang Beom Nam, Tae Dong Kwon, Hyun Kyu Lee, Kum Hee Chung, Youn Woo Lee
1Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea. ywleepain@yumc.yonsei.ac.kr
2Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
3Department of Anesthesiology and Pain Medicine, Pochon CHA University College of Medicine, Pochon, Korea.
Various anesthetic agents have been used in laryngeal microscopic surgery, because the airway is shared with the surgeon, there is a short operation duration and intense cardiovascular stimulation occurs during the surgery. Sufentanil is superior than other anesthetic agents in blocking the cardiovascular response to the airway stimulation and a short duration of effects.
Thirty patients undergoing elective laryngeal microscopic surgery were randomized to receive sufentanil 0.125 microgram/kg (group 1, n = 10), sufentanil 0.25 microgram/kg (group 2, n = 10) or sufentanil 0.5 microgram/kg (group 3, n = 10). The bispectral index score, blood pressure, heart rate, recovery time from general anesthesia, the need for additional analgesics and naloxone and the postoperative complications associated with sufentanil were measured.
The bispectral index, blood pressure and heart rate were similar in the three groups. Only four patients in group 3 required naloxone (P < 0.05). Three patients in group 1, one in group 2 and 0 in group 3 required an additional dose of sufentanil. Postoperative sore throat was detected in 6 patients in the immediate postoperative period and in 8 patients 6 hours after the end of anesthesia in group 1 (P < 0.05).
Sufentanil is an effective analgesic for attenuating the cardiovascular responses of airway stimulation in laryngeal microscopic surgery. In addition, sufentanil 0.25 microgram/kg is an appropriate dose for the rapid recovery and attenuation of the cardiovascular response in laryngeal microscopic surgery.
Key Words: bispectral index; cardiovascular response; laryngeal microscopic surgery; sufentanil
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