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Korean Journal of Anesthesiology 2006;50(2):179-183.
DOI: https://doi.org/10.4097/kjae.2006.50.2.179   
The Effects of Prophylactic Metoclopramide and Induction with Propofol on Postoperative Nausea and Vomiting.
Hyun Hee Park, Kwan Sik Park, Sook Young Lee, Oi Gyeong Cho, Jae Hyung Kim, Jin Soo Kim, Dong Wook Shin
1Department of Anesthesiology and Pain Medicine, School of Medicine, Ajou University, Suwon, Korea. anesylee@ajou.ac.kr
2Department of Anesthesiology and Pain Medicine, School of Medicine, Jeju University, Jeju, Korea.
Postoperative nausea and vomiting (PONV) are common problems in patients undergoing a laparoscopic cholecystectomy. This study evaluated the effect of prophylactic metoclopramide (MCP) and induction with propofol on PONV.
165 patients undergoing laparoscopic cholecystectomy were randomly divided into four groups. Groups 1 (control group) and 2 were inducted with thiopental sodium. Groups 3 (propofol group) and 4 were inducted with propofol. Prophylactic metoclopramide 10 mg i.v. was administered in Groups 2 (MCP group) and 4 (propofol + MCP group). The incidence of PONV, the need for rescue antiemetics, adverse events, and the nausea severity scores were assessed at 0 to 1 hour and at 1 to 24 hours postoperatively.
During the first 24 hours after anesthesia, the incidence of PONV in Groups 1, 2, 3 and 4 was 41.5%, 29.3%, 30.3% and 23.3%, respectively. There was no significant difference between the groups. During the period, 1 hour to 24 hours, after anesthesia, the incidence of PONV in Groups 1, 2, 3 and 4 was 36.6%, 17.4%, 27.5% and 14.4%, respectively. The incidence of PONV in Group 4 was significantly lower than in Group 1 (P < 0.05).
In patients with laparoscopic cholecystectomy, a combination of prophylactic metoclopramide administration and induction with propofol was found to reduce the incidence of PONV by about 22.6% during the period 1 hour to 24 hours after anesthesia.
Key Words: laparoscopic cholecystectomy; metoclopramide; postoperative nausea and vomiting (PONV); propofol


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