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Korean Journal of Anesthesiology 2006;51(4):468-475.
DOI: https://doi.org/10.4097/kjae.2006.51.4.468   
The Expression of alpha2-Adrenergic Receptor Subtypes in the Central Nervous System of Peripheral Nerve Injured Rats.
So Ron Choi, Hyung Chang Lee, Chan Jong Chung, Hae Kyu Kim
1Department of Anesthesiology and Pain Medicine, College of Medicine, Dong-A University, Korea. cjchung@dau.ac.kr
2Department of Anesthesiology and Pain Medicine, College of Medicine, Pusan National University, Busan, Korea.
The change of expression of the alpha2-adrenergic receptor (alpha(2)-AR) subtypes in the thalamus and hypothalamus were investigated in a neuropathic pain rat model.
The left sciatic nerve was clamped for creating a neuropathic pain model in five rats. A sham operation was done in three rats as control group. Behavioral tests for pain were conducted by using mechanical stimuli applied to the hind paws. After 7 days, the expression of alpha(2)-AR subtype mRNA in the rat thalamus and hypothalamus was measured using real time polymerase chain reaction.
Mechanical allodynia were developed on postoperative 1, 3, and 7 days in the neuropathic pain model. The expression of alpha(2A)-AR, alpha(2B)-AR, and alpha(2C)-AR was significantly higher in the thalamus and hypothalamus in the neuropathic pain model (P > 0.05).
These results would suggest that the subtypes of alpha(2)-AR in thalamus and hypothalamus may contribute to produce neuropathic pain.
Key Words: alpha(2)-adrenergic receptor; neuropathic pain; peripheral nerve injury; mechanical allodynia
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