Korean J Anesthesiol Search


Korean Journal of Anesthesiology 2004;46(4):393-396.
DOI: https://doi.org/10.4097/kjae.2004.46.4.393   
Effect of Ondansetron and Lidocaine on Vascular Pain Associated with Intravenous Propofol Injection.
Wha Ja Kang, Sung Ki Hong, Keon Sik Kim
Department of Anesthesiology and Pain Medicine, College of Medicine, Kyunghee University, Seoul, Korea.
Propofol has a high incidence of pain with intravenous injection, and different methods have been used to minimize the incidence and severity of this pain. In this study, we have compared the effect of lidocaine pretreatment with that of ondansetron pretreatment on propofol injection pain.
Ninety healthy female patients scheduled for general anesthesia were randomly divided into three groups; saline group (n = 30), lidocaine group (n = 30) and ondansetron groups (n = 30). Each patient received 2 ml of pretreatment solution (normal saline, 1% lidocaine, ondansetron) via 18 G angiocatheter inserted in the antecubital fossa after applying an arm tourniquet inflated to 50 mmHg. The tourniquet was released 1 minute later, followed by intravenous injection of 2.5 mg/kg of propofol. The assessment of pain was made at the induction of anesthesia and in the recovery room and the severity of pain was classified as none, mild, moderate, severe by one observer.
The severity and incidence of pain diminished significantly in the lidocaine group and the ondansetron group compared with the saline group at the induction of anesthesia (P < 0.05) and there was no significant difference between the lidocaine group and ondansetron group. We had similar results in the recovery room and one patient from the saline group and two patients from the ondansetron group had no recall regarding injection pain.
Intravenous ondansetron pretreatment is as effective as intravenous lidocaine pretreatment in alleviating the propofol injection pain.
Key Words: injection pain; lidocaine; ondansetron; propofol
Share :
Facebook Twitter Linked In Line it
METRICS Graph View
  • 3 Crossref
  • 1,357 View
  • 31 Download


Browse all articles >

Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2023 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next