Korean J Anesthesiol Search

CLOSE


Korean J Anesthesiol > Volume 42(5); 2002 > Article
Korean Journal of Anesthesiology 2002;42(5):634-640.
DOI: https://doi.org/10.4097/kjae.2002.42.5.634   
Combining Propofol with Opioid in Patient Controlled Analgesia to Prevent Post-Thoracotomy Nausea and Vomiting.
Hee Pyoung Park, Yong Seok Oh
Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea. yongseok@snu.ac.kr
Abstract
BACKGROUND
Subhypnotic doses of propofol have been demonstrated to possess a direct antiemetic property. The present study was designed to assess the antiemetic efficacy of propofol mixed the reservoir bag of an intravenous patient-controlled analgesia (PCA) in patients using an intravenous PCA after a thoracotomy.
METHODS
One-hundred seventy five subjects were allocated to two groups. Propofol was added to the PCA regimen to a concentration of 5 mg/ml in group P. The same volume of normal saline were substituted for propofol in group C. The PCA regimen was composed of ketorolac, fentanyl and morphine. The dosages of drugs were adjusted according to the patient's age and sex. The PCA was set at a basal rate of 0.5 ml/hr, bolus dose of 1 ml and a lockout interval of 10 min. The incidence and severity of PONV, sedation, pain and other side effect was assessed at 1, 4, 8, 12, 18, 24, 36, 48, 60 and 72 hr postoperatively.
RESULTS
There was no significant difference in the incidence and the severity of postoperative nausea and vomiting (PONV) between the two groups. Overall pain scores were not different between the two groups. The occurrence and the severity of sedation was significantly higher in group P compared to group C (P < 0.05).
CONCLUSIONS
Propofol added to a concentration of 5 mg/ml in a PCA regimen, composed of ketorolac, fentanyl and morphine, used for postoperative pain control is not effective in decreasing PONV in patients undergoing a thoracotomy.
Key Words: Nausea; patient-controlled analgesia; propofol; vomiting
TOOLS
Share :
Facebook Twitter Linked In Line it
METRICS Graph View
  • 0 Crossref
  •    
  • 744 View
  • 3 Download


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2022 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next