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Korean Journal of Anesthesiology 2003;44(2):158-162.
DOI: https://doi.org/10.4097/kjae.2003.44.2.158   
The Effect of Continuous Infusion of Alfentanil in Combination with Desflurane.
Dong Hee Kim
Department of Anesthesiology, College of Medicine, Dankook University, Cheon An, Korea. anedhkim@hanmail.net
Desflurane provides satisfactory surgical anesthesia when used alone or in combination with N2O or fentanyl or both. The goals of this study were to determine the effect of alfentanil infusion in the presence of desflurane and nitrous oxide.
Sixty patients undergoing plastic surgery were anesthetized with desflurane, 50% nitrousoxide, and alfentanil (10mu g/kg loading dose followed by 0.25mu g/kg/min infusion [group 1], 0.25mu g/kg/min infusion [group 2], no infusion [group 3]). The minimum alveolar concentration of desflurane, induction and recovery time, and perioperative side effects according to charge of the alfentanil regimen were checked.
Induction and recovery time were shorter in group 1 (20.2 min, 4.5 min) and group 2 (30.0 min, 4.2 min) than group 3 (48.1 min, 7.9 min) (P < 0.05). Minimum alveolar concentration of desflurane was lower in group 1 (3.6 vol%) and group 2 (3.7 vol%) than group 3 (6.7 vol%) (P < 0.05). Incidences of hypotension and bradycardia were significantly higher in group 1 than group 2 or 3 (P < 0.05).
We recommend 0.25mu g/kg infusion without a loading dose of alfentanil combined with 3.7 vol% of desflurane and 50% N2O as the best combination dosage in plastic surgery to shorten the induction and recovery time without significant side effects.
Key Words: Alfentanil; desflurane; induction time; recovery time


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