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Korean Journal of Anesthesiology 2003;44(2):169-175.
DOI: https://doi.org/10.4097/kjae.2003.44.2.169   
Changes in Serum Concentrations of Insulin-like Growth Factor-1 (IGF-1) during Different Methods of General Anesthesia.
Jong Hak Kim, Hee Jung Baik
Department of Anesthesiology, College of Medicine, Ewha Womans University, Seoul, Korea. kjhanes@mm.ewha.ac.kr
IGFs (insulin-like growth factors) exert acute anabolic effects on protein and carbohydrate metabolism, and have a long-term impact on cell proliferation, differentiation, and apoptosis. The purpose of this study was to evaluate whether serum levels of IGF-1 were affected by the general anesthetics.
Twenty patients, scheduled for a total abdominal hysterectomy were given either propofol (n = 10) or isoflurane (n = 10) general anesthesia. All patients were treated in a standardized manner in regard to surgical technique. Blood samples were taken before induction and at the time of peritoneal closure, postoperative 1 hour, and on postoperative days 2 and 5. Serum concentrations of IGF-1 were determined using an immunoradiometric assay.
IGF-1 levels decreased from the value before induction by 17.1% during surgery and 37.5% by day 5 in the propofol group. IGF-1 levels fell by 18.7% during surgery and returned to the preinduction level on day 5 after surgery in the isoflurane group. There were no differences in IGF-1 levels between the two groups with different methods of anesthesia.
Our study suggests that general anesthesia with isoflurane is associated with a less effect in serum IGF-1 level than propofol. However, further experimental and clinical studies are needed to establish the definitive effect of general anesthetics on IGF.
Key Words: General anesthesia; IGF-1; isoflurane; propofol


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